CDCP1, CUB structural domain-containing protein 1, alias CD318, UNQ2486, PRO5773, is encoded by the human CDCP1 gene. CDCP1 is a type I transmembrane glycoprotein located mainly on the cell surface and is involved in several key signaling pathways for tumorigenesis and metastasis, including SRC/PKCd, PI3K/AKT, WNT and RAS/ERK pathways, and fatty acid oxidation, which are important for cancer cell survival, growth, metastasis, and resistance to therapy.
The mechanism of action of CDCP1 involves interactions with a wide range of cancer-associated proteins and plays a role in tumor markers and potential therapeutic targets. CDCP1 is overexpressed in a wide range of malignant tumors, including respiratory tumors, digestive cancers, hematological malignancies and genitourinary cancers, correlates with tumor prognosis and drug resistance, and is considered a promising therapeutic target and new diagnostic biomarker.
Recombinant Human CUB domain-containing protein 1 (CDCP1), partial (Active) (CSB-MP884474HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CDCP1 at 2μg/mL can bind Anti-CDCP1 recombinant antibody (CSB-RA884474MA1HU),the EC50 is 0.2943-0.4429 ng/mL.
Recombinant Mouse CUB domain-containing protein 1 (Cdcp1), partial (Active) (CSB-MP719456MO)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Cdcp1 at 2 μg/mL can bind Anti-CDCP1 recombinant antibody (CSB-RA884474MA1HU), the EC50 is 0.6397-0.8369 ng/mL.
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CDCP1 at 2μg/mL can bind Anti-CDCP1 recombinant antibody (CSB-RA884474MA1HU),the EC50 is 1.861-2.330 ng/mL.
CDCP1 Antibody (CSB-PA884474ESR2HU)
Validated Data
Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA884474ESR2HU at dilution of 1:100
The following CDCP1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CDCP1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA442968 | CDCP1 Antibody | Human | ELISA,WB |
CSB-PA884474ESR2HU | CDCP1 Antibody | Human | ELISA, IHC |
CSB-PA001521 | CDCP1 Antibody | Human,Mouse | WB, ELISA |
CSB-PA005337 | CDCP1 Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA050067 | Phospho-CDCP1 (Y707) Antibody | Human,Mouse | WB, ELISA |
CSB-PA050068 | CDCP1 Antibody | Human,Mouse | WB, IF, ELISA |
CSB-PA251431 | CDCP1 Antibody | Human | ELISA,WB,IHC |
CSB-PA952668 | CDCP1 Antibody | Human | ELISA,WB,IHC |
CSB-RA884474MA1HU | CDCP1 Recombinant Monoclonal Antibody | Human, Mouse, Macaca fascicularis | ELISA |
CDCP1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP719456MO CSB-EP719456MO CSB-BP719456MO CSB-MP719456MO CSB-EP719456MO-B |
Recombinant Mouse CUB domain-containing protein 1 (Cdcp1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-MP719456MO | Recombinant Mouse CUB domain-containing protein 1 (Cdcp1), partial (Active) | Mammalian cell |
CDCP1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP884474HU CSB-EP884474HU CSB-BP884474HU CSB-MP884474HU CSB-EP884474HU-B |
Recombinant Human CUB domain-containing protein 1 (CDCP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-MP884474HU | Recombinant Human CUB domain-containing protein 1 (CDCP1), partial (Active) | Mammalian cell |