CLDN5

Claudin-5 (CLDN5), also known as CLD5 or SEMP1, is a core component of tight junctions in endothelial cells, essential for maintaining the integrity of the blood-brain barrier (BBB). It forms transmembrane complexes that seal paracellular gaps, restricting the passage of ions, macromolecules, and pathogens between cells.
Dysregulation of CLDN5 contributes to BBB disruption in stroke, multiple sclerosis, and glioblastoma. It interacts with pathways like Wnt/β-catenin and VEGF, which modulate barrier permeability. Current drug研发 focuses on peptides or small molecules targeting CLDN5 to restore BBB function, potentially treating neurological disorders and inhibiting tumor cell extravasation.

Validated Data

IHC image of CSB-RA037143A0HU diluted at 1:100 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.77% DAB.

CLDN5 Antibody (CSB-PA005507LA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA005507LA01HU at dilution of 1:100

Immunofluorescent analysis of MCF-7 cells using CSB-PA005507LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Human Claudin-5(CLDN5) ELISA kit (CSB-EL005507HU)

Validated Data

Code: CSB-EL005507HU

Size: 96T,5×96T,10×96T

Sensitivity: 7.8 pg/mL

Detection Range: 31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following CLDN5 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CLDN5 Antibodies

CLDN5 Proteins

CLDN5 ELISA Kits

CLDN5 Antibodies

CLDN5 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA275485	CLDN5 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA554477	Phospho-CLDN5 (Tyr217) Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA166761	CLDN5 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA001672	CLDN5 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA050270	Phospho-CLDN5 (Y217) Antibody	Human,Mouse,Rat	IHC, ELISA
CSB-PA050271	CLDN5 Antibody	Human,Mouse,Rat	IHC, ELISA
CSB-PA285560	CLDN5 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA578073	CLDN5 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA005507LA01HU	CLDN5 Antibody	Human	ELISA, IHC, IF
CSB-PA005507LC01HU	CLDN5 Antibody, FITC conjugated	Human
CSB-RA037143A0HU	CLDN5 Recombinant Monoclonal Antibody	Human	ELISA, IHC

CLDN5 Proteins

CLDN5 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF005507HU	Recombinant Human Claudin-5 (CLDN5)	in vitro E.coli expression system
CSB-YP005507HU1 CSB-EP005507HU1 CSB-BP005507HU1 CSB-MP005507HU1 CSB-EP005507HU1-B	Recombinant Human Claudin-5 (CLDN5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CLDN5 ELISA Kit

CLDN5 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL005507HU	Human Claudin-5(CLDN5) ELISA kit	serum, plasma, tissue homogenates	7.8 pg/mL

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CLDN5

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