DNASE1L3

Deoxyribonuclease 1 Like 3 (DNASE1L3), also known as DNase gamma, is a secreted endonuclease that cleaves chromatin DNA into mononucleosomes. It plays a critical role in clearing apoptotic cells and immune complexes, thereby maintaining immune tolerance by preventing self-DNA fragments from triggering autoimmunity.
Mutations in DNASE1L3 are strongly linked to systemic lupus erythematosus (SLE) and other autoimmune disorders, as defective enzyme function leads to accumulated self-DNA and autoantibody production. Current research focuses on recombinant DNASE1L3 or modulators to restore its activity, though clinical applications remain in preclinical stages.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

DNASE1L3 Antibody (CSB-PA621686EA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA621686EA01HU at dilution of 1:100

Human Deoxyribonuclease gamma(DNASE1L3) ELISA kit (CSB-EL007052HU)

Validated Data

Code: CSB-EL007052HU

Size: 96T,5×96T,10×96T

Sensitivity: 5.86 pg/mL

Detection Range: 23.44 pg/mL-1500 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following DNASE1L3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

DNASE1L3 Antibodies

DNASE1L3 Proteins

DNASE1L3 ELISA Kits

DNASE1L3 Antibodies

DNASE1L3 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA007052GA01HU	DNASE1L3 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA115883	DNASE1L3 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA621686EA01HU	DNASE1L3 Antibody	Human	ELISA, IHC
CSB-PA621686EB01HU	DNASE1L3 Antibody, HRP conjugated	Human	ELISA
CSB-PA621686EC01HU	DNASE1L3 Antibody, FITC conjugated	Human
CSB-PA621686ED01HU	DNASE1L3 Antibody, Biotin conjugated	Human	ELISA

DNASE1L3 Proteins

DNASE1L3 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP007052MO CSB-BP007052MO CSB-MP007052MO CSB-EP007052MO-B	Recombinant Mouse Deoxyribonuclease gamma (Dnase1l3)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP007052MO	Recombinant Mouse Deoxyribonuclease gamma (Dnase1l3)	E.coli
CSB-EP007052MOb0	Recombinant Mouse Deoxyribonuclease gamma (Dnase1l3)	E.coli

DNASE1L3 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP007052RA CSB-EP007052RA CSB-BP007052RA CSB-MP007052RA CSB-EP007052RA-B	Recombinant Rat Deoxyribonuclease gamma (Dnase1l3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

DNASE1L3 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP621686HU CSB-MP621686HU CSB-EP621686HU-B	Recombinant Human Deoxyribonuclease gamma (DNASE1L3)	Yeast Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP621686HU	Recombinant Human Deoxyribonuclease gamma (DNASE1L3)	E.coli
CSB-EP621686HUe1	Recombinant Human Deoxyribonuclease gamma (DNASE1L3)	E.coli
CSB-BP621686HU	Recombinant Human Deoxyribonuclease gamma (DNASE1L3)	Baculovirus
CSB-BP621686HUb1	Recombinant Human Deoxyribonuclease gamma (DNASE1L3)	Baculovirus
CSB-EP621686HUb1	Recombinant Human Deoxyribonuclease gamma (DNASE1L3)	E.coli
CSB-EP621686HUc7	Recombinant Human Deoxyribonuclease gamma (DNASE1L3)	E.coli
CSB-EP621686HUd7	Recombinant Human Deoxyribonuclease gamma (DNASE1L3)	E.coli
CSB-EP621686HUg5	Recombinant Human Deoxyribonuclease gamma (DNASE1L3)	E.coli
CSB-EP621686HUa0	Recombinant Human Deoxyribonuclease gamma (DNASE1L3)	E.coli

DNASE1L3 ELISA Kit

DNASE1L3 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL007052HU	Human Deoxyribonuclease gamma(DNASE1L3) ELISA kit	serum, plasma, tissue homogenates, cell lysates	5.86 pg/mL

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DNASE1L3

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