GUCY2C, also known as guanylate cyclase 2C (GC-C), is a transmembrane protein belonging to the receptor guanylate cyclase family. This protein is a receptor for the E.coli heat-stable enterotoxin (it is E.coli enterotoxin that markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). It is regulated by E.coli heat-stable enterotoxin (STa), guanylin and uroguanine. After activation, it transmits extracellular signaling into the cell and participates in the regulation of intestinal function.
GUCY2C is expressed in primary colorectal cancer cells, and the expression of GUCY2C in metastatic colorectal cancer cells is 2-10 times higher than that in normal intestinal epithelial cells. are expressed. In addition, GUCY2C is also expressed in pancreatic cancer, gastric cancer and esophageal cancer (accounting for 60%), the above information suggests that GUCY2C can be used as a target for these diseases.
● Recombinant Human Heat-stable enterotoxin receptor(GUCY2C),partial (Active) (CSB-MP010053HU)
Validated Data
Greater than 95% as determined by SDS-PAGE.
Immobilized human GUCY2C at 5 μg/ml can bind Anti-GUCY2C recombinant antibody (CSB-RA010053A2HU), the EC50 is 11.89-24.13 ng/mL.
● Recombinant Human Heat-stable enterotoxin receptor(GUCY2C),partial (Active) (CSB-MP010053HUd9)
Validated Data
Greater than 94.8% as determined by SDS-PAGE.
Immobilized human GUCY2C at 5 μg/ml can bind Anti-GUCY2C recombinant antibody (CSB-RA010053A2HU), the EC50 is 3.049-4.660 ng/mL.
The following GUCY2C reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
GUCY2C Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA010053LA01HU | GUCY2C Antibody |
Human, Mouse | ELISA, WB, IHC, IF |
CSB-PA010053LB01HU | GUCY2C Antibody, HRP conjugated |
Human | ELISA |
CSB-PA010053LC01HU | GUCY2C Antibody, FITC conjugated |
Human | |
CSB-PA010053LD01HU | GUCY2C Antibody, Biotin conjugated |
Human | ELISA |
CSB-RA010053A2HU | GUCY2C Recombinant Monoclonal Antibody |
Human | ELISA, FC |
CSB-RA010053A3HU | GUCY2C Recombinant Monoclonal Antibody |
Human | ELISA, FC |
GUCY2C Antibodies for Rattus norvegicus (Rat)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA010053ZA01RA | Gucy2c Antibody |
Rattus norvegicus | ELISA, WB (ensure identification of antigen) |
GUCY2C Proteins for Cavia porcellus (Guinea pig)
Code | Product Name | Source |
---|---|---|
CSB-YP010053GU CSB-EP010053GU CSB-BP010053GU CSB-MP010053GU CSB-EP010053GU-B |
Recombinant Guinea pig Heat-stable enterotoxin receptor (GUCY2C), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GUCY2C Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP010053RA | Recombinant Rat Heat-stable enterotoxin receptor (Gucy2c), partial |
Yeast |
CSB-EP010053RA | Recombinant Rat Heat-stable enterotoxin receptor (Gucy2c), partial |
E.coli |
CSB-BP010053RA | Recombinant Rat Heat-stable enterotoxin receptor (Gucy2c), partial |
Baculovirus |
CSB-MP010053RA | Recombinant Rat Heat-stable enterotoxin receptor (Gucy2c), partial |
Mammalian cell |
GUCY2C Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP010053PI CSB-EP010053PI CSB-BP010053PI CSB-MP010053PI CSB-EP010053PI-B |
Recombinant Pig Heat-stable enterotoxin receptor (GUCY2C), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GUCY2C Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP010053HU CSB-EP010053HU CSB-EP010053HU-B |
Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial |
Yeast E.coli In Vivo Biotinylation in E.coli |
CSB-BP010053HU | Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial |
Baculovirus |
CSB-MP010053HU | Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) |
Mammalian cell |
CSB-MP010053HUd9 | Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) |
Mammalian cell |
GUCY2C Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP664972MO CSB-EP664972MO CSB-EP664972MO-B |
Recombinant Mouse Heat-stable enterotoxin receptor (Gucy2c), partial |
Yeast E.coli In Vivo Biotinylation in E.coli |
CSB-BP664972MO | Recombinant Mouse Heat-stable enterotoxin receptor (Gucy2c), partial |
Baculovirus |
CSB-MP664972MO | Recombinant Mouse Heat-stable enterotoxin receptor (Gucy2c), partial |
Mammalian cell |