Hydroxycarboxylic acid receptor 2 is a protein in humans that is encoded by HCAR2 gene. Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
The following HCAR2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
HCAR2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA078796 | HCAR2 Antibody |
Human,Mouse,Rat | ELISA,IHC |
CSB-PA095731 | HCAR2 Antibody |
Human,Mouse,Rat | ELISA,IHC |
HCAR2 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-CF768919RA | Recombinant Rat Hydroxycarboxylic acid receptor 2 (Hcar2) |
in vitro E.coli expression system |
CSB-YP768919RA1 CSB-EP768919RA1 CSB-BP768919RA1 CSB-MP768919RA1 CSB-EP768919RA1-B |
Recombinant Rat Hydroxycarboxylic acid receptor 2 (Hcar2), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HCAR2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF866800MO | Recombinant Mouse Hydroxycarboxylic acid receptor 2 (Hcar2) |
in vitro E.coli expression system |
CSB-YP866800MO1 CSB-EP866800MO1 CSB-BP866800MO1 CSB-MP866800MO1 CSB-EP866800MO1-B |
Recombinant Mouse Hydroxycarboxylic acid receptor 2 (Hcar2), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HCAR2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF840573HU | Recombinant Human Hydroxycarboxylic acid receptor 2 (HCAR2) |
in vitro E.coli expression system |
CSB-YP840573HU1 CSB-EP840573HU1 CSB-BP840573HU1 CSB-MP840573HU1 CSB-EP840573HU1-B |
Recombinant Human Hydroxycarboxylic acid receptor 2 (HCAR2), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |