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Hypoxia-inducible factor 1-alpha is a protein in humans that is encoded by HIF1A gene. Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2.
The following HIF1A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
HIF1A Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA010351GA01HU | HIF1A Antibody |
Human,Mouse,Rat | ELISA,IHC |
| CSB-PA12807A0Rb | HIF1A Antibody |
Human | ELISA, IHC, IF |
| CSB-PA12807B0Rb | HIF1A Antibody, HRP conjugated |
Human | ELISA |
| CSB-PA12807C0Rb | HIF1A Antibody, FITC conjugated |
Human | |
| CSB-PA12807D0Rb | HIF1A Antibody, Biotin conjugated |
Human | ELISA |
| CSB-PA930291 | HIF1A Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA952643 | HIF1A Antibody |
Human,Mouse,Rat | ELISA,WB |
| CSB-PA000432 | HIF1A Antibody |
Mouse,Rat | WB |
| CSB-PA002906 | HIF1A Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA077072 | HIF1A Antibody |
Human | ELISA,IHC |
| CSB-PA968396 | HIF1A Antibody |
Human | ELISA,WB,IHC |
| CSB-PA928186 | HIF1A Antibody |
Human,Mouse,Rat | ELISA,WB |
| CSB-PA578243 | HIF1A Antibody |
Human,Mouse,Rat | ELISA,WB |
| CSB-RA263943A0HU | HIF1A Antibody |
Human | ELISA, IF |
HIF1A Proteins for Rattus norvegicus (Rat)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP010351RA CSB-EP010351RA CSB-BP010351RA CSB-MP010351RA CSB-EP010351RA-B |
Recombinant Rat Hypoxia-inducible factor 1-alpha(Hif1a) ,partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HIF1A Proteins for Bos mutus grunniens (Wild yak) (Bos grunniens)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP611302BPD CSB-EP611302BPD CSB-BP611302BPD CSB-MP611302BPD CSB-EP611302BPD-B |
Recombinant Bos mutus grunniens Hypoxia-inducible factor 1-alpha(HIF1A) ,partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HIF1A Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP624113HU CSB-EP624113HU CSB-BP624113HU CSB-MP624113HU CSB-EP624113HU-B |
Recombinant Human Hypoxia-inducible factor 1-alpha(HIF1A) ,partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-RP128074h | Recombinant Human Hypoxia-inducible factor 1-alpha(HIF1A),partial |
E.coli |
HIF1A Proteins for Eospalax fontanierii baileyi (Plateau zokor) (Eospalax baileyi)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP653038EAAY CSB-EP653038EAAY CSB-BP653038EAAY CSB-MP653038EAAY CSB-EP653038EAAY-B |
Recombinant Eospalax baileyi Hypoxia-inducible factor 1-alpha(HIF1A) ,partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HIF1A Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP730731MO CSB-EP730731MO CSB-BP730731MO CSB-MP730731MO CSB-EP730731MO-B |
Recombinant Mouse Hypoxia-inducible factor 1-alpha(Hif1a) ,partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HIF1A Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP858481OEI CSB-EP858481OEI CSB-BP858481OEI CSB-MP858481OEI CSB-EP858481OEI-B |
Recombinant Oncorhynchus mykiss Hypoxia-inducible factor 1-alpha(hif1a) ,partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HIF1A Proteins for Xenopus laevis (African clawed frog)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP867421XBE CSB-EP867421XBE CSB-BP867421XBE CSB-MP867421XBE CSB-EP867421XBE-B |
Recombinant Xenopus laevis Hypoxia-inducible factor 1-alpha(hif1a) ,partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HIF1A Proteins for Bos taurus (Bovine)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP895019BO CSB-EP895019BO CSB-BP895019BO CSB-MP895019BO CSB-EP895019BO-B |
Recombinant Bovine Hypoxia-inducible factor 1-alpha(HIF1A) ,partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HIF1A Proteins for Gallus gallus (Chicken)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP896655CH CSB-EP896655CH CSB-BP896655CH CSB-MP896655CH CSB-EP896655CH-B |
Recombinant Chicken Hypoxia-inducible factor 1-alpha(HIF1A) ,partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HIF1A ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E12112h | Human hypoxia-inducible factor 1α(HIF-1α) ELISA kit |
serum, plasma, tissue homogenates | 15.6 pg/mL |
HIF1A ELISA Kit for Mus musculus (Mouse)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E08541m | Mouse hypoxia-inducible factor 1α,HIF-1α ELISA Kit |
serum, plasma | 0.156 pg/mL |
HIF1A ELISA Kit for Rattus norvegicus (Rat)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E08540r | Rat hypoxia-inducible factor 1α,HIF-1α ELISA Kit |
serum, plasma, tissue homogenates | 0.78 pg/mL |
Hypoxia-inducible factor 1-alpha is a protein in humans that is encoded by the HIF1A gene. The HIF1A protein functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, HIF1 activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF1A plays an essential role in embryonic vascularization, tumor angiogenesis, and pathophysiology of ischemic disease. It binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation of HIF1A requires the recruitment of transcriptional coactivators such as CREBBP and EP300. Its activity is enhanced by interaction with both, NCOA1 or NCOA2.
