IGFLR1

IGFR1, also known as IGF-1R (Insulin-Like Growth Factor 1 Receptor), is a cell surface receptor that plays a crucial role in cell growth, proliferation, and survival. IGFR1 is activated by two peptide hormones, Insulin-Like Growth Factor 1 (IGF-1) and Insulin-Like Growth Factor 2 (IGF-2).When IGF-1 or IGF-2 binds to IGFR1, it triggers a signaling cascade that promotes cell division, growth, and differentiation. This receptor is essential both during development and in the maintenance of tissues in adulthood. However, dysregulation of the IGF-1R signaling pathway has been linked to various diseases, including cancer.

In cancer research, IGFR1 has been studied as a potential target for cancer therapy. Inhibiting the activity of IGFR1 can be a strategy to slow down cancer cell growth and reduce tumor progression. Understanding the structure and function of IGFR1 is crucial for the development of targeted treatments in the field of oncology.

Popular Product

● Recombinant Human IGF-like family receptor 1(IGFLR1),partial (Active) CSB-MP862025HUd9

Validated Data

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IGFLR1 at 2 μg/ml can bind Human IGFL1 (CSB-MP764932HUh8), the EC₅₀ is 4.640-5.722 ng/mL.

● Recombinant Human IGF-like family receptor 1(IGFLR1),partial (Active) CSB-MP862025HU

Validated Data

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IGFLR1 at 2 μg/ml can bind Human IGFL1 (CSB-MP764932HU), the EC₅₀ is 32.33-47.52 ng/mL.