KDR

KDR, Kinase Domain-containing Receptor, also known as Vascular Endothelial Growth Factor Receptor 2. KDR is a transmembrane receptor tyrosine kinase that is expressed predominantly in vascular endothelial cells and is involved in the regulation of angiogenesis and maintenance of vascular integrity. Its mechanism of action involves binding to VEGF family members, such as VEGFA, VEGFC and VEGFD, and activation triggers receptor dimerisation and its own tyrosine kinase activity, which in turn triggers downstream signalling pathways, such as PI3K-Akt, Ras-Raf-MEK-ERK, etc, that promote endothelial cell proliferation, migration and increased vascular permeability. development, tissue repair, and wound healing, and is essential for normal physiological functions.

Meanwhile, the function of KDR is also critical in a variety of pathological states, especially in tumour angiogenesis, where its over-activation is closely associated with the progression and metastasis of a variety of tumours, making it an important target for cancer therapy. In addition, KDR plays a role in certain cardiovascular diseases and is a potential target for research and treatment of related diseases.