KDR, Kinase Domain-containing Receptor, also known as Vascular Endothelial Growth Factor Receptor 2. KDR is a transmembrane receptor tyrosine kinase that is expressed predominantly in vascular endothelial cells and is involved in the regulation of angiogenesis and maintenance of vascular integrity. Its mechanism of action involves binding to VEGF family members, such as VEGFA, VEGFC and VEGFD, and activation triggers receptor dimerisation and its own tyrosine kinase activity, which in turn triggers downstream signalling pathways, such as PI3K-Akt, Ras-Raf-MEK-ERK, etc, that promote endothelial cell proliferation, migration and increased vascular permeability. development, tissue repair, and wound healing, and is essential for normal physiological functions.
Meanwhile, the function of KDR is also critical in a variety of pathological states, especially in tumour angiogenesis, where its over-activation is closely associated with the progression and metastasis of a variety of tumours, making it an important target for cancer therapy. In addition, KDR plays a role in certain cardiovascular diseases and is a potential target for research and treatment of related diseases.
Recombinant Human Vascular endothelial growth factor receptor 2 (KDR), partial (CSB-EP012145HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
KDR Antibody (CSB-PA07279A0Rb)
Validated Data
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA07279A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA07279A0Rb at dilution of 1:100
The following KDR reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
KDR Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA07279A0Rb | KDR Antibody | Human | ELISA, IHC |
CSB-PA07279B0Rb | KDR Antibody, HRP conjugated | Human | ELISA |
CSB-PA07279C0Rb | KDR Antibody, FITC conjugated | Human | |
CSB-PA07279D0Rb | KDR Antibody, Biotin conjugated | Human | ELISA |
CSB-PA012145GA01HU | KDR Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA898056 | Phospho-KDR (Tyr1175) Antibody | Human,Mouse,Rat | ELISA,IHC,IF |
CSB-PA917275 | Phospho-KDR (Tyr1214) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
CSB-PA200726 | Phospho-KDR (Tyr951) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA905984 | KDR (Ab-1175) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA274392 | KDR (Ab-1214) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
CSB-PA920878 | KDR (Ab-951) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA444815 | Phospho-KDR (Tyr1059) Antibody | Human,Mouse | ELISA,WB |
CSB-PA070091 | KDR (Ab-1059) Antibody | Human,Mouse | ELISA,WB |
CSB-PA000527 | Phospho-KDR (Y1175) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA000528 | Phospho-KDR (Y1214) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA002542 | KDR Antibody | Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA002543 | KDR Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA009633 | Phospho-KDR (Y951) Antibody | Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA009634 | Phospho-KDR (Y1059) Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA009638 | KDR Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA009642 | KDR Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA490567 | KDR Antibody | Human,Mouse,Rat | IHC,ELISA |
CSB-RA012145MA1HU | KDR Recombinant Monoclonal Antibody | Human | ELISA, IHC |
KDR Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA708034XA01DIL | kdr Antibody | Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
KDR Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP012145MO CSB-EP012145MO CSB-BP012145MO CSB-MP012145MO CSB-EP012145MO-B |
Recombinant Mouse Vascular endothelial growth factor receptor 2 (Kdr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KDR Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP012145HU CSB-BP012145HU CSB-EP012145HU-B |
Recombinant Human Vascular endothelial growth factor receptor 2 (KDR), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
CSB-EP012145HU | Recombinant Human Vascular endothelial growth factor receptor 2 (KDR), partial | E.coli |
CSB-MP012145HU | Recombinant Human Vascular endothelial growth factor receptor 2 (KDR), partial | Mammalian cell |
CSB-MP012145HUd7 | Recombinant Human Vascular endothelial growth factor receptor 2 (KDR),partial | Mammalian cell |
KDR Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP012145RA CSB-EP012145RA CSB-BP012145RA CSB-MP012145RA CSB-EP012145RA-B |
Recombinant Rat Vascular endothelial growth factor receptor 2 (Kdr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KDR Proteins for Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
Code | Product Name | Source |
---|---|---|
CSB-YP346773DXJ CSB-EP346773DXJ CSB-BP346773DXJ CSB-MP346773DXJ CSB-EP346773DXJ-B |
Recombinant Coturnix coturnix japonica Vascular endothelial growth factor receptor 2 (KDR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KDR Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Source |
---|---|---|
CSB-YP708034DIL CSB-EP708034DIL CSB-BP708034DIL CSB-MP708034DIL CSB-EP708034DIL-B |
Recombinant Danio rerio Vascular endothelial growth factor receptor 2 (kdr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KDR ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04763h | Human Vascular endothelial cell growth factor receptor 2,VEGFR-2/Flk-1 ELISA kit | serum, plasma, tissue homogenates | 0.098 ng/mL |
KDR ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04764m | Mouse Vascular endothelial cell growth factor receptor 2,VEGFR-2/Flk-1 ELISA kit | serum, plasma, tissue homogenates | 1.95 pg/mL |
KDR ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E07348r | Rat Vascular endothelial cell growth factor receptor 2,VEGFR-2/Flk-1 ELISA kit | serum, plasma, tissue homogenates | 0.39 ng/mL |