Neural cell adhesion molecule L1(L1CAM), also known as CD171, is a cell adhesion receptor, belonging to the immunoglobulin superfamily. Originally discovered in the human brain, L1CAM plays an important role in the initiation and development of the nervous system by regulating cell-to-cell adhesion, including axonal growth and migration. Later, it was found that L1CAM protein is also highly expressed in malignant tumors originating from neural tissue, epithelial or mesothelial tissue and other tissues, such as non-small cell lung cancer, glioma, ovarian cancer, thyroid cancer, melanoma, gastric cancer, etc., and play an important role in tumor cell proliferation, infiltration, metastasis, anti-apoptosis and angiogenesis.
In the early stage of tumorigenesis, the expression of L1CAM is less, and it mainly exerts the function of adhesion between cells, which makes the tumor localized growth. As the tumor progresses, the expression of L1CAM can induce the expression of more adhesion molecules and adhesion molecule receptors, and activate the subsequent adhesion mechanism and signal transduction, thereby promoting tumor invasion and metastasis. At present, the detection of L1CAM protein has become a marker for evaluating the malignancy and prognosis of various tumors such as ovarian cancer, endometrial cancer and melanoma.
Recombinant Human Neural cell adhesion molecule L1(L1CAM),partial (Active) (CSB-MP012704HU1)
Validated Data
Greater than 95% as determined by SDS-PAGE.
Immobilized L1CAM at 2 μg/ml can bind Anti-L1CAM Rabbit Monoclonal Antibody (CSB-RA595071A0HU), the EC50 is 5.384-9.380 ng/ml.
The following L1CAM reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
L1CAM Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA07439A0Rb | L1CAM Antibody |
Human, Mouse | ELISA, WB, IHC, IF |
CSB-PA07439B0Rb | L1CAM Antibody, HRP conjugated |
Human | ELISA |
CSB-PA07439D0Rb | L1CAM Antibody, Biotin conjugated |
Human | ELISA |
CSB-PA003380 | L1CAM Antibody |
Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA009695 | Phospho-L1CAM (S1181) Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA078460 | L1CAM Antibody |
Human,Mouse,Rat | ELISA,IHC |
CSB-PA266419 | L1CAM Antibody |
Human,Mouse,Rat | IHC,ELISA |
L1CAM Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP012704MO CSB-EP012704MO CSB-BP012704MO CSB-MP012704MO CSB-EP012704MO-B |
Recombinant Mouse Neural cell adhesion molecule L1(L1cam) ,partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
L1CAM Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-BP012704HU CSB-MP012704HU CSB-EP012704HU-B |
Recombinant Human Neural cell adhesion molecule L1(L1CAM),partial |
Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP012704HU | Recombinant Human Neural cell adhesion molecule L1(L1CAM),partial |
E.coli |
CSB-YP012704HU | Recombinant Human Neural cell adhesion molecule L1(L1CAM),partial |
Yeast |
CSB-MP012704HU1 | Recombinant Human Neural cell adhesion molecule L1(L1CAM),partial (Active) |
Mammalian cell |
L1CAM Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Code | Product Name | Source |
---|---|---|
CSB-YP847465TKY CSB-EP847465TKY CSB-BP847465TKY CSB-MP847465TKY CSB-EP847465TKY-B |
Recombinant Takifugu rubripes Neural cell adhesion molecule L1(l1cam) ,partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
L1CAM ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E09145h | Human Neural cell adhesion molecule ligand 1,NCAM-L1 ELISA Kit |
serum, plasma, tissue homogenates | 0.31 ng/mL |