MICB

The MICB gene encodes the MHC class I polypeptide-related sequence B protein. Also known as MHC class I chain-related protein B, it is a critical component of the immune system. MICB binds to the NKG2D receptor on natural killer (NK) cells and some T cells, activating immune responses. This interaction is involved in the NKG2D-mediated signaling pathway, which helps the immune system recognize and eliminate infected or stressed cells.
Dysregulation of MICB is associated with several diseases, including certain cancers and autoimmune disorders. In cancer, abnormal expression of MICB can affect immune surveillance. Currently, there is ongoing research to develop drugs targeting the MICB-NKG2D interaction for immunotherapy, aiming to enhance anti - tumor immune responses.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human MICB at 2 μg/ml can bind Anti-MICA/B recombinant antibody (CSB-RA56059MA1HU). The EC₅₀ is 1.087-1.369 ng/mL.

Human MHC class I polypeptide-related sequence B(MICB) ELISA kit (CSB-EL013813HU)

Validated Data

Code: CSB-EL013813HU

Size: 96T,5×96T,10×96T

Sensitivity: 7.8 pg/mL

Detection Range: 31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following MICB reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

MICB Proteins

MICB ELISA Kits

MICB Proteins

MICB Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-BP013813HU CSB-EP013813HU-B	Recombinant Human MHC class I polypeptide-related sequence B (MICB), partial	Baculovirus In Vivo Biotinylation in E.coli
CSB-AP000271HU	Recombinant Human MHC class I polypeptide-related sequence B protein (MICB)	E.coli
CSB-MP013813HU	Recombinant Human MHC class I polypeptide-related sequence B (MICB), partial	Mammalian cell
CSB-EP013813HU	Recombinant Human MHC class I polypeptide-related sequence B (MICB), partial	E.coli
CSB-YP013813HU	Recombinant Human MHC class I polypeptide-related sequence B (MICB), partial	Yeast
CSB-MP013813HUd7	Recombinant Human MHC class I polypeptide-related sequence B (MICB), partial (Active)	Mammalian cell

MICB ELISA Kit

MICB ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL013813HU	Human MHC class I polypeptide-related sequence B(MICB) ELISA kit	serum, plasma, tissue homogenates	7.8 pg/mL

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MICB

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