NMT2, another N-myristoyltransferase, also plays an indispensable role in cellular activities. Structurally, NMT2 exhibits a three-dimensional structure similar to NMT1, enabling it to perform analogous biological functions, namely catalyzing the N-myristoylation modification of proteins. Specifically, NMT2 is primarily responsible for catalyzing the N-terminal myristoylation of specific proteins, a crucial lipid modification process that affects the function and localization of signaling proteins. This modification plays a pivotal role in cell signal transduction, protein localization, and interactions with other molecules. Similar to NMT1, abnormal expression or dysfunction of NMT2 may be closely associated with the occurrence and development of diseases. Through its catalytic activity, NMT2 influences the myristoylation status of signaling proteins, thereby regulating the activation or inhibition of signaling pathways. These signaling pathways involve key processes such as cell proliferation, differentiation, and apoptosis. Additionally, NMT2 may interact with other molecules and proteins, forming complex regulatory networks. These interactions may involve crosstalk among multiple signaling pathways, enabling fine-tuned regulation of cellular functions.
Validated Data
Immunoprecipitating NMT2 in HepG2 whole cell lysate
Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA015901DSR1HU in HepG2 whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
Lane 2: CSB-PA015901DSR1HU (4μg) + HepG2 whole cell lysate (500μg)
Lane 3: HepG2 whole cell lysate (20μg)
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA015901DSR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA015901DSR1HU at dilution of 1:100
The following NMT2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
NMT2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA213831 | NMT2 Antibody |
Human,Mouse | ELISA,IHC |
CSB-PA158660 | NMT2 Antibody |
Human,Mouse | ELISA,WB,IHC |
CSB-PA015901DSR1HU | NMT2 Antibody |
Human | ELISA, IHC, IP |
CSB-PA015901DSR2HU | NMT2 Antibody |
Human | ELISA, WB, IHC, IP |
NMT2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP015901HU CSB-EP015901HU CSB-BP015901HU CSB-MP015901HU CSB-EP015901HU-B |
Recombinant Human Glycylpeptide N-tetradecanoyltransferase 2 (NMT2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |