PDGFD

PDGFD, or platelet-derived growth factor D, is a cytokine encoded by the PDGFD gene and part of the platelet-derived growth factor family. It is involved in processes such as angiogenesis, tissue repair, and immune response. PDGFD's mechanism of action includes binding to the PDGFR-β receptor and activating downstream signaling pathways like PI3K/AKT and RAS/RAF/MEK/ERK. It is implicated in the regulation of cell proliferation, migration, differentiation, and angiogenesis, with dysfunction associated with diseases such as atherosclerosis, tumor angiogenesis, and inflammatory bowel disease. PDGFD is a potential target for research and treatment in cardiovascular diseases, tumors, and inflammatory diseases.