RIPK1

RIPK, Receptor Interacting Serine/Threonine Protein Kinase 1, alias RIP1.RIPK1 is a cytoplasmic protein kinase that regulates multiple inflammatory and cell death pathways. Its role in the tumor necrosis factor receptor 1 (TNFR1) signaling pathway has been extensively studied, and its kinase activity is critical for the regulatory process.RIPK1 can participate in the formation of multiple signaling complexes, such as complex I (TNF-RSC), which promotes the activation of NF-κB and the inhibition of its kinase activity through ubiquitination modifications, thereby inhibiting RIPK1-dependent processes during embryogenesis and inflammatory RIPK1 is biologically significant, not only in the regulation of apoptosis, necroptosis and inflammatory signaling pathways, but also in embryonic development, hematopoietic development, and maintenance of immune homeostasis, etc.

Abnormalities in RIPK1 function have been associated with a wide range of diseases including autoimmune deficiencies, autoinflammatory diseases, acromegaly, rheumatoid arthritis, and other diseases. diseases, including autoimmune deficiency, autoinflammatory diseases, acromegaly, rheumatoid arthritis, and colitis. Small molecule drugs targeting RIPK1 are in clinical trials for the treatment of these diseases. In addition, post-translational modifications such as phosphorylation and ubiquitination of RIPK1 play a key role in the regulation of its activity under both physiological and pathological conditions.