SMO, Smoothened, is a cell surface receptor that belongs to the class F G protein-coupled receptor (GPCR) family and is a key component of the Hedgehog (Hh) signaling pathway.SMO binds to Hh ligands in the cell, and when activated, it can transmit signals to the nucleus, which in turn activates the GLI transcription factor and regulates the expression of related genes. The origin of SMO is the gene code of human cells, and its mechanism of action involves the interaction with various proteins and lipid molecules, especially the covalent modification of cholesterol is crucial to the function of SMO.
SMO is of great significance in biology, which not only participates in the regulation of embryonic development, tissue regeneration and organ repair, but also is closely related to the occurrence and development of many types of cancer. The Hh signaling pathway is inhibited by Patched (PTCH) protein in the resting state; when Hh ligand binds to PTCH, the inhibition of SMO is lifted, thus activating the downstream signaling pathway. In addition, the aberrant activation of SMO is closely related to the development of gliomas and other tumors, making SMO an important target for anti-cancer drug development .
Validated Data
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA155823(SMO Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA155823(SMO Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
The following SMO reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SMO Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA050108 | SMO Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA155823 | SMO Antibody | Human,Rat | ELISA,IHC |
CSB-PA857876LA01HU | SMO Antibody | Human, Mouse | ELISA, WB, IF |
CSB-PA857876LB01HU | SMO Antibody, HRP conjugated | Human | ELISA |
CSB-PA857876LC01HU | SMO Antibody, FITC conjugated | Human | |
CSB-PA857876LD01HU | SMO Antibody, Biotin conjugated | Human | ELISA |
CSB-PA288930GA01HU | SMO Antibody | Human, Mouse, Rat | ELISA, WB |
SMO Antibodies for Drosophila melanogaster (Fruit fly)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA309724XA01DLU | smo Antibody | Drosophila melanogaster (Fruit fly) | ELISA, WB (ensure identification of antigen) |
SMO Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF857876HU | Recombinant Human Smoothened homolog (SMO) | in vitro E.coli expression system |
CSB-YP857876HU1 CSB-EP857876HU1 CSB-BP857876HU1 CSB-MP857876HU1 CSB-EP857876HU1-B |
Recombinant Human Smoothened homolog (SMO), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SMO Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF021841MO | Recombinant Mouse Smoothened homolog (Smo) | in vitro E.coli expression system |
CSB-YP021841MO1 CSB-EP021841MO1 CSB-BP021841MO1 CSB-MP021841MO1 CSB-EP021841MO1-B |
Recombinant Mouse Smoothened homolog (Smo), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SMO Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-CF021841RA | Recombinant Rat Smoothened homolog (Smo) | in vitro E.coli expression system |
CSB-YP021841RA1 CSB-EP021841RA1 CSB-BP021841RA1 CSB-MP021841RA1 CSB-EP021841RA1-B |
Recombinant Rat Smoothened homolog (Smo), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SMO Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-CF021841CH | Recombinant Chicken Smoothened homolog (SMO) | in vitro E.coli expression system |
CSB-YP021841CH1 CSB-EP021841CH1 CSB-BP021841CH1 CSB-MP021841CH1 CSB-EP021841CH1-B |
Recombinant Chicken Smoothened homolog (SMO), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SMO Proteins for Drosophila melanogaster (Fruit fly)
Code | Product Name | Source |
---|---|---|
CSB-YP309724DLU CSB-EP309724DLU CSB-BP309724DLU CSB-MP309724DLU CSB-EP309724DLU-B |
Recombinant Drosophila melanogaster Protein smoothened (smo), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |