TNFSF15

TNFSF15, also known as Vascular Endothelial Growth Inhibitor (VEGI) or TL1A, is a protein encoded by the TNFSF15 gene located on chromosome 9q32. This protein, composed of 251 amino acids, encompasses a cytoplasmic domain, a transmembrane domain, and an extracellular domain, and is capable of forming a stable homotrimeric structure. Primarily serving as a ligand for Death Receptor 3 (DR3), TNFSF15 participates in regulating the VEGF/VEGFR signaling pathway, affecting processes such as endothelial cell proliferation, apoptosis, and lymphangiogenesis. It plays a crucial role in angiogenesis, lymphangiogenesis, immune regulation, and other biological processes, and offers new therapeutic targets for pathological conditions involving increased vascular permeability, such as tumors and strokes.

More Interesting read related TNFSF15: TNFSF15/TL1A,The Rise of the Next Billion-Dollar Target as Pharma Giants Stake Their Claims

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF15 at 2 μg/ml on streptavidin coated plates can bind Anti-TNFSF15 antibody (CSB-RA023992MA1HU). The EC₅₀ is 0.2732 - 0.6370 ng/mL.

Recombinant Macaca mulatta Tumor necrosis factor ligand superfamily member 15 (TNFSF15), partial, Biotinylated (Active) (CSB-MP5305MOW-B)

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Anti-TNFSF15 recombinant antibody (CSB-RA023992MA1HU) at 2 μg/ml can bind Biotinylated Macaca mulatta TNFSF15. The EC₅₀ is 0.2589-0.3025 ng/mL.

TNFSF15 Recombinant Monoclonal Antibody (CSB-RA023992MA1HU)

Validated Data

The Binding Activity of Biotinylated Macaca mulatta TNFSF15 with Anti-TNFSF15 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Anti-TNFSF15 recombinant antibody at 2 μg/mL can bind Biotinylated Macaca mulatta TNFSF15 (CSB-MP5305MOW-B). The EC₅₀ is 0.2589-0.3025 ng/mL.

The Binding Activity of Biotinylated TNFSF15 with Anti-TNFSF15 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Biotinylated Human TNFSF15 at 2 μg/mL on streptavidin coated plates can bind Anti-TNFSF15 recombinant antibody (CSB-RA023992MA1HU). The EC₅₀ is 0.2732 - 0.6370 ng/mL.

The Binding Activity of Mouse Tnfsf15 with Anti-TNFSF15 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Tnfsf15 (CSB-MP729268MO) at 2 μg/mL can bind Anti-TNFSF15 recombinant antibody. The EC₅₀ is 1.671-2.506 ng/mL.

The following TNFSF15 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

TNFSF15 Antibodies

TNFSF15 Proteins

TNFSF15 ELISA Kits

TNFSF15 Antibodies

TNFSF15 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA983205	TNFSF15 Antibody	Human	ELISA,WB,IF
CSB-PA004447	TNFSF15 Antibody	Human	WB, IF, ELISA
CSB-PA577745	TNFSF15 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA065340	TNFSF15 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA023992ESR1HU	TNFSF15 Antibody	Human, Mouse	ELISA, WB
CSB-PA023992ESR2HU	TNFSF15 Antibody	Human	ELISA, IHC
CSB-RA023992MA1HU	TNFSF15 Recombinant Monoclonal Antibody	Human, Cynomolgus, Mouse	ELISA

TNFSF15 Proteins

TNFSF15 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-AP002341HU	Recombinant Human Tumor necrosis factor ligand superfamily member 15 protein (TNFSF15), partial (Active)	E.Coli
CSB-CF023992HU	Recombinant Human Tumor necrosis factor ligand superfamily member 15 (TNFSF15)	in vitro E.coli expression system
CSB-YP023992HU1 CSB-EP023992HU1 CSB-BP023992HU1 CSB-EP023992HU1-B	Recombinant Human Tumor necrosis factor ligand superfamily member 15 (TNFSF15), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-AP004991HU	Recombinant Human Tumor necrosis factor ligand superfamily member 15 (TNFSF15) (Active)	E.coli
CSB-MP023992HU(F2)	Recombinant Human Tumor necrosis factor ligand superfamily member 15(TNFSF15) (Active)	Mammalian cell
CSB-MP023992HU1-B	Recombinant Human Tumor necrosis factor ligand superfamily member 15(TNFSF15),partial,Biotinylated (Active)	Mammalian cell

TNFSF15 ELISA Kit

TNFSF15 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E15770h	Human tumor necrosis factor superfamily 15 (TL1A/TNFSF15) ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	0.195 ng/mL

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TNFSF15

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