Necroptosis

What is Necroptosis?

Necroptosis is a programmed form of necrosis, and is an alternative mode of regulated cell death mimicking features of apoptosis and necrosis.

Generally, cell demise and its survival are the fundamental features of metazoans to maintain the tissue homeostasis. On morphological basis, cell death is achieved by apoptosis, necrosis, and autophagy.

A plenty of studies has been performed on apoptosis and autophagy and reveals a clear picture of molecular mechanisms of apoptosis and autophagy which is recognized as a highly regulated process. Hence, apoptosis and autophagy are usually regarded as “programmed cell death”, but necrosis is considered as “un-programmed” due to deregulated activity.

What is The Function of Necroptosis?

Necroptosis is specific to vertebrates and may have originated as an additional defense to pathogens. Necroptosis also acts as an alternative "fail-safe" cell death pathway in cases where cells are unable to undergo apoptosis, such as during viral infection in which apoptosis signaling proteins are blocked by the virus.

Additionally, recent studies implicate it in a variety of disease states. In myocardial infarction and stroke, atherosclerosis, ischemia-reperfusion injury, pancreatitis, inflammatory bowel disease and a number of other clinically common disorders, necroptosis is of central pathophysiological relevance.

The process of Necroptosis

Necroptosis is a newly discovered pathway of regulated necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3.

RIPK1 has important kinase-dependent and scaffolding functions that inhibit or trigger necroptosis and apoptosis. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.

Target

Antibody

Protein

Clone

ELISA Kit

H2AFJ H2AFJ Antibody H2AFJ Protein H2AFJ cDNA H2AFJ ELISA Kit
H2AFV H2AFV Antibody H2AFV Protein H2AFV cDNA H2AFV ELISA Kit
H2AFX H2AFX Antibody H2AFX Protein H2AFX cDNA H2AFX ELISA Kit
H2AFY H2AFY Antibody H2AFY Protein H2AFY cDNA H2AFY ELISA Kit
H2AFY2 H2AFY2 Antibody H2AFY2 Protein H2AFY2 cDNA H2AFY2 ELISA Kit
H2AFZ H2AFZ Antibody H2AFZ Protein H2AFZ cDNA H2AFZ ELISA Kit
HIST1H2AA HIST1H2AA Antibody HIST1H2AA Protein HIST1H2AA cDNA HIST1H2AA ELISA Kit
HIST1H2AC HIST1H2AC Antibody HIST1H2AC Protein HIST1H2AC cDNA HIST1H2AC ELISA Kit
HIST1H2AD HIST1H2AD Antibody HIST1H2AD Protein HIST1H2AD cDNA HIST1H2AD ELISA Kit
HIST1H2AH HIST1H2AH Antibody HIST1H2AH Protein HIST1H2AH cDNA HIST1H2AH ELISA Kit
HIST1H2AJ HIST1H2AJ Antibody HIST1H2AJ Protein HIST1H2AJ cDNA HIST1H2AJ ELISA Kit
HIST2H2AB HIST2H2AB Antibody HIST2H2AB Protein HIST2H2AB cDNA HIST2H2AB ELISA Kit
HIST2H2AC HIST2H2AC Antibody HIST2H2AC Protein HIST2H2AC cDNA HIST2H2AC ELISA Kit
HIST3H2A HIST3H2A Antibody HIST3H2A Protein HIST3H2A cDNA HIST3H2A ELISA Kit
HMGB1 HMGB1 Antibody HMGB1 Protein HMGB1 cDNA HMGB1 ELISA Kit
HSP90AA1 HSP90AA1 Antibody HSP90AA1 Protein HSP90AA1 cDNA HSP90AA1 ELISA Kit
HSP90AB1 HSP90AB1 Antibody HSP90AB1 Protein HSP90AB1 cDNA HSP90AB1 ELISA Kit
IFNA1 IFNA1 Antibody IFNA1 Protein IFNA1 cDNA IFNA1 ELISA Kit
IFNA10 IFNA10 Antibody IFNA10 Protein IFNA10 cDNA IFNA10 ELISA Kit
IFNA13 IFNA13 Antibody IFNA13 Protein IFNA13 cDNA IFNA13 ELISA Kit
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