CD147

CD147, also known as Basigin or EMMPRIN, is a transmembrane protein belonging to the immunoglobulin superfamily, featuring an extracellular N-terminus and an intracellular C-terminus. It possesses an Ig-like (immunoglobulin-like) extracellular domain that engages in interactions with other proteins. CD147 is extensively expressed in various cell types, including immune cells, leukocytes, erythrocytes, neurons, glial cells, and tumor cells. It plays a crucial role in cell adhesion and migration processes, participating in diverse biological processes such as cell proliferation, invasion, metastasis, as well as the activation of immune cells and inflammatory responses. In the realm of oncology, CD147 is regarded as a tumor-associated marker due to its significantly elevated expression levels on the surface of multiple tumor cells, correlating with tumor cell invasion and metastasis. CD147 also participates in regulating cell-cell interactions within the tumor microenvironment, exerting a discernible influence on tumor growth and progression. Additionally, CD147 plays a pivotal role in immune regulation and infection processes. It is intricately linked to pathogen infection, inflammatory responses, and the activation and migration of immune cells. Thus, it emerges as a prospective target for disease treatment and new drug development.

Popular Product

● Recombinant Human Basigin(BSG),partial (Active)

Validated Data

High Purity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized CD147 at 2 μg/ml can bind Anti-CD147 recombinant Antibody, the EC₅₀ is 21.95-33.12 ng/ml.

● CD147 Recombinant Monoclonal Antibody CSB-RA002831A0HU

Validated Data

Western Blot

Positive WB detected in: HepG2 whole cell lysate, ntera2 whole cell lysate, A549 whole cell lysate, U251 whole cell lysate
All lanes: CD147 antibody at 1:1000
Secondary
Goat polyclonal to mouse IgG at 1/50000 dilution
Predicted band size: 42, 29, 23, 19 KDa Observed band size: 35, 50-60 KDa