Cyclin-dependent kinase 4 is a protein in humans that is encoded by CDK4 gene. Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity.

CDK4 Antibodies

CDK4 Antibodies for Homo sapiens (Human)

CDK4 Proteins

CDK4 Proteins for Sus scrofa (Pig)

CDK4 Proteins for Homo sapiens (Human)

CDK4 Proteins for Mus musculus (Mouse)

CDK4 Proteins for Rattus norvegicus (Rat)

CDK4 Proteins for Xenopus laevis (African clawed frog)

CDK4 Proteins for Bos taurus (Bovine)


CDK4 ELISA Kit for Homo sapiens (Human)


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