CHRM5

The protein encoded by CHRM5 is Cholinergic Receptor Muscarinic 5 (M5 receptor), a G protein-coupled receptor (GPCR) subtype. Upon acetylcholine binding, it activates Gq/11 signaling, triggering phospholipase C-mediated inositol trisphosphate production and intracellular calcium release, regulating neuronal activity in brain reward and cognitive regions.
CHRM5 is linked to schizophrenia (cognitive impairments) and substance use disorders (e.g., cocaine addiction). Selective M5 antagonists are under preclinical evaluation for reducing drug-seeking behaviors and enhancing cognitive function; early trials suggest potential therapeutic value, though further clinical validation is needed.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CHRM5 Antibody (CSB-PA005385LA01HU)

Validated Data

Western Blot
Positive WB detected in: Mouse liver tissue, Mouse kidney tissue, Mouse brain tissue
All lanes: CHRM5 antibody at 3.5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 61 kDa
Observed band size: 61 kDa

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA005385LA01HU at dilution of 1:100

Immunofluorescent analysis of A549 cells using CSB-PA005385LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

The following CHRM5 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CHRM5 Antibodies

CHRM5 Proteins

CHRM5 Antibodies

CHRM5 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA006813	CHRM5 Antibody	Human	WB, IF, ELISA
CSB-PA985994	CHRM5 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA598098	CHRM5 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA005385LA01HU	CHRM5 Antibody	Human, Mouse	ELISA, WB, IHC, IF

CHRM5 Proteins

CHRM5 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF005385RA	Recombinant Rat Muscarinic acetylcholine receptor M5 (Chrm5)	in vitro E.coli expression system
CSB-YP005385RA1 CSB-EP005385RA1 CSB-BP005385RA1 CSB-MP005385RA1 CSB-EP005385RA1-B	Recombinant Rat Muscarinic acetylcholine receptor M5 (Chrm5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CHRM5 Proteins for Pan troglodytes (Chimpanzee)

Code	Product Name	Source
CSB-CF683299EQV	Recombinant Pan troglodytes Muscarinic acetylcholine receptor M5 (CHRM5)	in vitro E.coli expression system
CSB-YP683299EQV1 CSB-EP683299EQV1 CSB-BP683299EQV1 CSB-MP683299EQV1 CSB-EP683299EQV1-B	Recombinant Pan troglodytes Muscarinic acetylcholine receptor M5 (CHRM5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CHRM5 Proteins for Saimiri boliviensis boliviensis (Bolivian squirrel monkey)

Code	Product Name	Source
CSB-CF702443SWC	Recombinant Saimiri boliviensis boliviensis Muscarinic acetylcholine receptor M5 (CHRM5)	in vitro E.coli expression system
CSB-YP702443SWC1 CSB-EP702443SWC1 CSB-BP702443SWC1 CSB-MP702443SWC1 CSB-EP702443SWC1-B	Recombinant Saimiri boliviensis boliviensis Muscarinic acetylcholine receptor M5 (CHRM5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CHRM5 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF856351MO	Recombinant Mouse Muscarinic acetylcholine receptor M5 (Chrm5)	in vitro E.coli expression system
CSB-YP856351MO1 CSB-EP856351MO1 CSB-BP856351MO1 CSB-MP856351MO1 CSB-EP856351MO1-B	Recombinant Mouse Muscarinic acetylcholine receptor M5 (Chrm5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CHRM5 Proteins for Macaca mulatta (Rhesus macaque)

Code	Product Name	Source
CSB-CF005385MOW	Recombinant Macaca mulatta (Rhesus macaque) Muscarinic acetylcholine receptor M5 (CHRM5)	in vitro E.coli expression system
CSB-YP005385MOW1 CSB-EP005385MOW1 CSB-BP005385MOW1 CSB-MP005385MOW1 CSB-EP005385MOW1-B	Recombinant Macaca mulatta (Rhesus macaque) Muscarinic acetylcholine receptor M5 (CHRM5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CHRM5 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF005385HU	Recombinant Human Muscarinic acetylcholine receptor M5 (CHRM5)	in vitro E.coli expression system
CSB-YP005385HU1 CSB-BP005385HU1 CSB-MP005385HU1 CSB-EP005385HU1-B	Recombinant Human Muscarinic acetylcholine receptor M5 (CHRM5), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP005385HU1	Recombinant Human Muscarinic acetylcholine receptor M5 (CHRM5), partial	E.coli
CSB-MP005385HU	Recombinant Human Muscarinic acetylcholine receptor M5 (CHRM5)-VLPs	Mammalian cell

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CHRM5

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