E7

The E7 protein possesses transformation activity and transactivation ability. Its structure comprises two functional domains: one is the N-terminal region containing the conserved Cys-X-X-Cys (CXXC) motif, responsible for interacting with specific proteins within the cell; the other is the C-terminal region, including the conserved LXCXE sequence, which binds to the Retinoblastoma protein (Rb) within the cell. By binding to the Rb protein, the E7 protein inhibits the function of Rb, leading to uncontrolled cell cycle and abnormal proliferation. This causes cells to lose their normal growth suppression mechanisms, promoting cellular transformation and carcinogenesis. Research on E7 targets and its interaction with the Rb protein has become a crucial direction in HPV-related cancer treatment and vaccine development. E7 is one of the key proteins in HPV infection, closely associated with processes such as cell cycle regulation, transcriptional control, and cell proliferation.

Popular Product:

● Recombinant Human papillomavirus type 16 Protein E7 (E7)

Validated Data

SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LC-MS/MS

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP365855HML could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) E7.

LC-MS/MS

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP365855HML could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) E7.

● Recombinant Human papillomavirus type 18 Protein E7 (E7)

Validated Data

SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.