ERBB3

ERBB3 is a gene providing an instruction of making a protein named receptor tyrosine-protein kinase erbB-3 (also abbreviated as ERBB3) and is located on the long arm of human chromosome 12 (12q13). ERBB3 protein, also known as HER3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family with a molecular weight of 160 or 180 kDa.

ERBB3 is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium. Indeed, ERBB3 itself is regulated by two ubiquitin ligases, NEDD4 and NRDP1, which regulate its ubiquitination and proteasomal degradation. Overexpression of ERBB3 was found to be associated in many cancers, including prostate, bladder, and breast cancers.

ERBB3 cannot be autophosphorylated due to the absence of intrinsic tyrosine kinase activity, but ERBB3 is able to form heterodimers with other members of EGFR family, ERBB1/HER1, ERBB2/HER2, and ERBB4. The heterodimers provide an approach to activate downstream pathways that affect cell proliferation and differentiation. Among them, the ERBB3/ERBB2 heterodimer is considered the most active of the ERBB3 dimers and exhibits a higher signaling activity than other heterodimers. This heterodimer conformation allows the signaling complex to activate multiple pathways including MAPK/ERK and PI3K/AKT.

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Popular Product

Recombinant Human Receptor tyrosine-protein kinase erbB-3(ERBB3),partial (Active) (CSB-MP007765HU)

Validated Data

Purity determined
by SDS-PAGE

Greater than 95% as determined by SDS-PAGE.

The binding activity of NRG1-ERBB3 validated by functional ELISA

Immobilized NRG1 (CSB-MP016077HU1(F6)) at 2 μg/ml can bind human ERBB3, the EC₅₀ is 12.32-15.74 ng/ml.