NECTIN4 Research Reagents

NECTIN4 is a gene providing an instruction of making a protein named nectin cell adhesion molecule 4 (also known as Nectin-4). Nectin-4 is a member of the Nectin family and consists of three parts, including an extracellular domain containing three immunoprotein-like structures, a connecting structure across the cell membrane, and a tail structure located in the cytoplasm.

Nectin-4 is mainly formed in the embryonic period and expressed in all fetal tissues and organs and adult placenta, but it is not found in normal adult tissues and blood. As a member of the immunoglobulin-like cell adhesion molecule family, Nectin-4 is involved in the connection between cells and controls cell activities including cell polarization, differentiation, migration, proliferation, and survival.

As a new tumor-associated antigen, Nectin-4 is overexpressed in various tumor cells, such as urothelial carcinoma, breast carcinoma, pancreatic carcinoma, triple negative breast carcinoma and bladder carcinoma. Nectin-4 promotes tumor cell proliferation, differentiation, migration, invasion, etc. by activating the PI3K/Akt pathway. Therefore, targeting Nectin-4 as a therapeutic target may become an effective strategy for the treatment of cancers with high expression of Nectin-4.

Popular Product

Recombinant Human Nectin-4(NECTIN4),partial (Active) (CSB-MP822274HU)

Validated Data

Purity determined
by SDS-PAGE

Greater than 95% as determined by SDS-PAGE.

The binding activity of antigen-antibody validated by functional ELISA

Immobilized NECTIN4 at 2 μg/ml can bind anti-NECTIN4 antibody (CSB-RA822274A0HU) (enfortumab vedotin-like), the EC₅₀ is 0.6029-0.7837 ng/mL.