NECTIN4, or connexin cell adhesion molecule 4, alias LNIR, PRR4, EDSS1, PVRL4. NECTIN4 protein is a transmembrane cell adhesion molecule belonging to the Nectins family of immunoglobulin-like molecules with an extracellular structural region consisting of an IGV loop and two IGC loops, a transmembrane structural domain, and a cytoplasmic structural domain that contains an afadin binding motif.
NECTIN4 is involved in intercellular adhesion through interactions with other Nectins molecules, forming physical junctions between neighboring cells that are essential for enabling intercellular communication, migration, and other important cellular processes.
NECTIN4 is overexpressed in a variety of tumors, such as uroepithelial carcinoma, breast cancer, and pancreatic cancer, while its expression in normal tissues is low. Overexpression of NECTIN4 is associated with tumor cell proliferation, differentiation, migration, invasion and other processes, and promotes tumor cell proliferation and migration mainly through activation of the PI3K/Akt pathway, which is a potential target for tumor therapy, especially an important target in the therapeutic strategy of antibody-drug-coupled compounds (ADCs).
Recombinant Human Nectin-4 (NECTIN4), partial (Active) (CSB-MP822274HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized NECTIN4 at 2 μg/ml can bind anti-NECTIN4 antibody(CSB-RA822274A0HU)(enfortumab vedotin-like), the EC50 is 0.6029-0.7837 ng/mL.
NECTIN4 Recombinant Monoclonal Antibody (CSB-RA822274A0HU)
Validated Data
The Binding Activity of NECTIN4 with Anti-NECTIN4 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human NECTIN4(CSB-MP822274HU) at 2 μg/mL can bind Anti-NECTIN4 recombinant antibody, the EC50 is 0.6029-0.7837 ng/mL.
The following NECTIN4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
NECTIN4 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA060216 | PVRL4 Antibody | Human | WB, ELISA |
CSB-PA190585 | PVRL4 Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA232987 | PVRL4 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA822274LA01HU | NECTIN4 Antibody | Human, Mouse, Rat | ELISA, WB, IF |
CSB-PA822274LB01HU | NECTIN4 Antibody, HRP conjugated | Human | ELISA |
CSB-PA822274LC01HU | NECTIN4 Antibody, FITC conjugated | Human | |
CSB-PA822274LD01HU | NECTIN4 Antibody, Biotin conjugated | Human | ELISA |
CSB-RA822274A0HU | NECTIN4 Recombinant Monoclonal Antibody | Human | ELISA |
NECTIN4 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Code | Product Name | Source |
---|---|---|
CSB-YP702045XBF CSB-EP702045XBF CSB-BP702045XBF CSB-MP702045XBF CSB-EP702045XBF-B |
Recombinant Xenopus tropicalis Poliovirus receptor-related protein 4 (pvrl4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NECTIN4 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP707822BO CSB-EP707822BO CSB-BP707822BO CSB-MP707822BO CSB-EP707822BO-B |
Recombinant Bovine Poliovirus receptor-related protein 4 (PVRL4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NECTIN4 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP822274HU | Recombinant Human Nectin-4 (NECTIN4), partial | Yeast |
CSB-EP822274HU CSB-BP822274HU CSB-EP822274HU-B |
Recombinant Human Nectin-4 (NECTIN4), partial | E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-AP005571HU | Recombinant Human Nectin-4 (NECTIN4), partial (Active) | Mammalian cell |
CSB-MP822274HU | Recombinant Human Nectin-4 (NECTIN4), partial (Active) | Mammalian cell |
NECTIN4 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP844423MO CSB-EP844423MO CSB-BP844423MO CSB-MP844423MO CSB-EP844423MO-B |
Recombinant Mouse Poliovirus receptor-related protein 4 (Pvrl4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |