RSPO1

R-Spondin 1 (RSPO1) is a secreted glycoprotein with aliases including CRISTIN3 and RSPO. It potentiates Wnt/β-catenin signaling by bridging LGR4/5/6 receptors and RNF43/ZNRF3 E3 ubiquitin ligases, blocking ligase-mediated degradation of Wnt receptors (FZD/LRP5/6) to stabilize cytoplasmic β-catenin, which translocates to the nucleus and regulates target gene expression.
RSPO1 mutations are linked to 46,XX testicular disorder of sex development and primary ovarian insufficiency. Its overexpression drives Wnt pathway activation in colorectal and breast cancers. Preclinical inhibitors targeting RSPO1-LGR interaction are evaluated for Wnt-dependent tumors, while recombinant RSPO1 shows promise in repairing intestinal epithelial damage.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human RSPO1 at 2 μg/ml can bind Human LGR5(CSB-MP012906HU1), the EC₅₀ is 124.0-174.1 ng/mL.

Recombinant Human R-spondin-1 (RSPO1) (CSB-MP644834HU)

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

RSPO1 Antibody (CSB-PA644834DSR1HU)

Validated Data

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA644834DSR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA644834DSR1HU at dilution of 1:100

Human R-spondin-1(RSPO1) ELISA kit (CSB-EL020550HU)

Validated Data

Code: CSB-EL020550HU

Size: 96T,5×96T,10×96T

Sensitivity: 15.6 pg/mL

Detection Range: 62.5 pg/mL-4000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following RSPO1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

RSPO1 Antibodies

RSPO1 Proteins

RSPO1 ELISA Kits

RSPO1 Antibodies

RSPO1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA644834DSR1HU	RSPO1 Antibody	Human	ELISA, IHC

RSPO1 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Species Reactivity	Application
CSB-PA724931XA01DIL	rspo1 Antibody	Danio rerio (Zebrafish) (Brachydanio rerio)	ELISA, WB (ensure identification of antigen)

RSPO1 Proteins

RSPO1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP644834HU CSB-EP644834HU CSB-BP644834HU CSB-EP644834HU-B	Recombinant Human R-spondin-1 (RSPO1)	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-AP005721HU	Recombinant Human R-spondin-1 (RSPO1), partial (Active)	Mammalian cell
CSB-MP644834HU1	Recombinant Human R-spondin-1 (RSPO1), partial (Active)	Mammalian cell
CSB-MP644834HU-WD	Recombinant Human R-spondin-1 (RSPO1) (Active)	Mammalian cell
CSB-MP644834HU	Recombinant Human R-spondin-1 (RSPO1)	Mammalian cell

RSPO1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Source
CSB-YP724931DIL CSB-EP724931DIL CSB-BP724931DIL CSB-MP724931DIL CSB-EP724931DIL-B	Recombinant Danio rerio R-spondin-1 (rspo1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

RSPO1 ELISA Kit

RSPO1 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL020550HU	Human R-spondin-1(RSPO1) ELISA kit	serum, plasma, tissue homogenates	15.6 pg/mL

RSPO1 ELISA Kit for Mus musculus (Mouse)

Code	Product Name	Sample Types	Sensitivity
CSB-EL020550MO	Mouse R-spondin-1(RSPO1) ELISA kit	serum, plasma, tissue homogenates	1.56 pg/mL

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RSPO1

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