Function
(From Uniprot) |
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (By similarity). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity). |
| Gene References into Functions |
- TGF-beta1 is activated or inactivated by MMP20 or KLK4 and that the amelogenin cleavage product is necessary for the in-solution mobility of TGF-beta1. PMID: 27633089
- Activated TGF-beta signaling rescued miR-143-reduced FSHR and intracellular signaling molecules, and miR-143-induced porcine granulosa cell apoptosis. PMID: 27882941
- TGF-beta1-induced epithelial-myofibroblast plasticity is FAK- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK signaling is inhibited. PMID: 28360109
- this study shows that TGF-beta1 protects intestinal integrity and influences Smad and MAPK signal pathways in intestinal epithelium cells after TNF-alpha challenge PMID: 28142299
- this study shows that anemonin may ameliorate LPS-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR signaling pathways PMID: 27189428
- The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress. PMID: 25170924
- Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance. PMID: 24042214
- The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10, and IL-6 in ovarian follicles are reported. PMID: 24020676
- Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet. PMID: 23602250
- TGF-beta1, via TGF-beta1 receptor I and p38 MAPK signaling, reduces CFTR expression to impair CFTR-mediated anion secretion, which would likely compound the effects associated with mild CFTR mutations and ultimately would compromise male fertility. PMID: 23903699
- High yield isolation of BMP-2 from bone and in vivo activity of a combination of BMP-2/TGF-beta1. PMID: 22927042
- Boar seminal plasma contained TGF- beta1 and IL-10 but with high individual variation. PMID: 22482797
- The present study was aimed to determine the association between metalloproteinase 3 (MMP3), transforming growth factor beta 1 (TGFbeta1) and collagen type X alpha I (COL10A1) gene polymorphisms with traits related to leg weakness in pigs. PMID: 21739142
- Inhibition of transforming growth factor beta-1 augments liver regeneration after partial portal vein ligation in a porcine experimental model. PMID: 22251543
- TGF-beta prevents excessive heart valve growth under normal physiological conditions while it promotes cell proliferation in the early stages of repair. PMID: 21851806
- Crystals of dimeric porcine proTGF-beta1 reveal a ring-shaped complex, a novel fold for the prodomain, and show how the prodomain shields the growth factor from recognition by receptors and alters its conformation. PMID: 21677751
- The effects of different polymorphisms of TGF-beta1 on litter size in Large white pigs are reported. PMID: 20088852
- TGF-beta disrupts an IGF-II-stimulated autocrine amplification cascade that is necessary for muscle differentiation in vitro. PMID: 21106882
- beta-Catenin plays a critical role in mediating TGF-beta1-induced myofibroblast differentiation in aortic valve interstitial cells. PMID: 21127288
- Results suggest that Rac1 and RhoA are regulated by TGFbeta1 in the process of endothelial tube formation in collagen I gels. PMID: 16978608
- TGFbeta may play a role in the overall process of luteinization, but it appears not to influence steroidogenesis in luteinizing pig follicles. PMID: 20378284
- Elevated circulating TGF-beta(1) causes endothelial dysfunction through NADPH oxidase activation-induced oxidative stress, accelerating atherosclerosis and hypertension in apoE(-/-) mice. PMID: 20511416
- TGFbeta stimulation of ANK expression is dependent upon the influx of phosphate and calcium into ATDC5 cells at all stages of differentiation. PMID: 20432454
- Data suggest that focal adhesion kinase (FAK)-SMAD 2/3 mediate signal crosstalk between type II collagen and TGF-beta1 and regulate glycosaminoglycan secretion in chondrocytic cells. PMID: 19840848
- show that histone deacetylase 4 overexpression promotes TGF-beta1-induced synovium-derived stem cells chondrogenesis but inhibits chondrogenically differentiated stem cell hypertrophy. PMID: 19716643
- multiple effects of TGFbeta at the porcine conceptus-maternal interface, including integrin-mediated conceptus-maternal communication through LAP PMID: 15961561
- Repeated injection of adenovirus expressing porcine TGF-beta1 may be useful model for studying Peyronie's disease. PMID: 17651407
- identification of six quantitative trait loci for diabetes-related traits in F(2)-D Tgf/Tgf and F(2)-C Tgf/Tgf pigs PMID: 18160996
- FGF2 effectively blocks transforming growth factor-beta1 (TGF-beta1)-mediated myofibroblast activation PMID: 18218921
- Using the model of porcine aortic endothelial cells, we demonstrated that TGFbeta stimulates cellular spreading when cells are on collagen I; TGFbeta-stimulated Rac1-GTP accumulation, which was associated with increased MAPK p38 phosphorylation. PMID: 18387002
- Wounding activates valve interstitial cell (VICs), and TGF-beta signaling modulates VIC response to injury. PMID: 18832581
- Altered shear stress stimulates upregulation of endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGF-beta1-dependent pathway. PMID: 19023092
- pTGF-beta1 induces human fibroblast synthesis & secretion of ET-1. TGF-beta1 activation of PI3K/AKT is not dependent on ET-1. ET-1 & TGF-beta1 independently promote fibroblast resistance to apoptosis through p38 MAPK & PI3K/AKT. PMID: 19188658
- transforming growth factor beta has a role in the regulation of thyroid function and growth [review] PMID: 19645615
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