The phosphatidylinositol 3' –kinase (PI3K)-Akt signaling pathway is an intracellular signaling pathway important in regulating the cell cycle and is activated by many types of cellular stimuli or toxic insults.
It regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival in response to extracellular signals. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates.
As shown in following picture, activation of growth factor receptor protein tyrosine kinases including epidermal growth factor receptor (EGFR) by external growth factors results in auto-phosphorylation on tyrosine residues and subsequent events to activate these intracellular pathways.
PI3K is recruited to the membrane by directly binding to phosphotyrosine consensus residues of growth factor receptors or adaptors through one or both SH2 domains in the adaptor subunit. This leads to allosteric activation of the catalytic subunit. Activation results in production of the second messenger phosphatidylinositol-3, 4, 5-trisphosphate (PIP3).
The lipid product of PI3K, PIP3, recruits a subset of signaling proteins with pleckstrin homology (PH) domains to the membrane, including PDK1 and Akt. PTEN, is a PI-3, 4, 5-P3 phosphatase, which negatively regulates the PI3K/Akt pathway.
Once activated, Akt mediates the activation and inhibition of several targets, resulting in cellular survival, growth and proliferation through various mechanisms.
In the mechanism of PI3K-Akt signaling pathway, the key molecules involved in this signaling pathway are receptor tyrosine kinase (RTKs), phosphatidylinositol 3-kinase (PI3K), phosphatidylinositol-4,5-bisphosphate (PIP2), phosphatidylinositol-3,4,5-bisphosphate (PIP3) and AKT/protein kinase B. You can click the link below to view more introduction of the two critical molecules https://www.cusabio.com/c-20715.html.
This article was written by a sweet guy from CUSABIO named PI3K-Akt Signaling Pathway and Cancer, including its history, mechanism and related diseases.
|CCNE1||CCNE1 Antibody||CCNE1 Protein||CCNE1 cDNA||CCNE1 ELISA Kit|
|CCNE2||CCNE2 Antibody||CCNE2 Protein||CCNE2 cDNA||CCNE2 ELISA Kit|
|CD19||CD19 Antibody||CD19 Protein||CD19 cDNA||CD19 ELISA Kit|
|CDC37||CDC37 Antibody||CDC37 Protein||CDC37 cDNA||CDC37 ELISA Kit|
|CDK2||CDK2 Antibody||CDK2 Protein||CDK2 cDNA||CDK2 ELISA Kit|
|CDK4||CDK4 Antibody||CDK4 Protein||CDK4 cDNA||CDK4 ELISA Kit|
|CDK6||CDK6 Antibody||CDK6 Protein||CDK6 cDNA||CDK6 ELISA Kit|
|CDKN1A||CDKN1A Antibody||CDKN1A Protein||CDKN1A cDNA||CDKN1A ELISA Kit|
|CDKN1B||CDKN1B Antibody||CDKN1B Protein||CDKN1B cDNA||CDKN1B ELISA Kit|
|CHAD||CHAD Antibody||CHAD Protein||CHAD cDNA||CHAD ELISA Kit|
|CHRM1||CHRM1 Antibody||CHRM1 Protein||CHRM1 cDNA||CHRM1 ELISA Kit|
|CHRM2||CHRM2 Antibody||CHRM2 Protein||CHRM2 cDNA||CHRM2 ELISA Kit|
|CHUK||CHUK Antibody||CHUK Protein||CHUK cDNA||CHUK ELISA Kit|
|COL1A1||COL1A1 Antibody||COL1A1 Protein||COL1A1 cDNA||COL1A1 ELISA Kit|
|COL1A2||COL1A2 Antibody||COL1A2 Protein||COL1A2 cDNA||COL1A2 ELISA Kit|
|COL2A1||COL2A1 Antibody||COL2A1 Protein||COL2A1 cDNA||COL2A1 ELISA Kit|
|COL4A1||COL4A1 Antibody||COL4A1 Protein||COL4A1 cDNA||COL4A1 ELISA Kit|
|COL4A2||COL4A2 Antibody||COL4A2 Protein||COL4A2 cDNA||COL4A2 ELISA Kit|
|COL4A3||COL4A3 Antibody||COL4A3 Protein||COL4A3 cDNA||COL4A3 ELISA Kit|
|COL4A4||COL4A4 Antibody||COL4A4 Protein||COL4A4 cDNA||COL4A4 ELISA Kit|