The phosphatidylinositol 3' –kinase (PI3K)-Akt signaling pathway is an intracellular signaling pathway important in regulating the cell cycle and is activated by many types of cellular stimuli or toxic insults.
It regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival in response to extracellular signals. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates.
As shown in following picture, activation of growth factor receptor protein tyrosine kinases including epidermal growth factor receptor (EGFR) by external growth factors results in auto-phosphorylation on tyrosine residues and subsequent events to activate these intracellular pathways.
PI3K is recruited to the membrane by directly binding to phosphotyrosine consensus residues of growth factor receptors or adaptors through one or both SH2 domains in the adaptor subunit. This leads to allosteric activation of the catalytic subunit. Activation results in production of the second messenger phosphatidylinositol-3, 4, 5-trisphosphate (PIP3).
The lipid product of PI3K, PIP3, recruits a subset of signaling proteins with pleckstrin homology (PH) domains to the membrane, including PDK1 and Akt. PTEN, is a PI-3, 4, 5-P3 phosphatase, which negatively regulates the PI3K/Akt pathway.
Once activated, Akt mediates the activation and inhibition of several targets, resulting in cellular survival, growth and proliferation through various mechanisms.
In the mechanism of PI3K-Akt signaling pathway, the key molecules involved in this signaling pathway are receptor tyrosine kinase (RTKs), phosphatidylinositol 3-kinase (PI3K), phosphatidylinositol-4,5-bisphosphate (PIP2), phosphatidylinositol-3,4,5-bisphosphate (PIP3) and AKT/protein kinase B. You can click the link below to view more introduction of the two critical molecules https://www.cusabio.com/c-20715.html.
This article was written by a sweet guy from CUSABIO named PI3K-Akt Signaling Pathway and Cancer, including its history, mechanism and related diseases.
|INSR||INSR Antibody||INSR Protein||INSR cDNA||INSR ELISA Kit|
|IRS1||IRS1 Antibody||IRS1 Protein||IRS1 cDNA||IRS1 ELISA Kit|
|ITGA1||ITGA1 Antibody||ITGA1 Protein||ITGA1 cDNA||ITGA1 ELISA Kit|
|ITGA11||ITGA11 Antibody||ITGA11 Protein||ITGA11 cDNA||ITGA11 ELISA Kit|
|ITGA2||ITGA2 Antibody||ITGA2 Protein||ITGA2 cDNA||ITGA2 ELISA Kit|
|ITGA2B||ITGA2B Antibody||ITGA2B Protein||ITGA2B cDNA||ITGA2B ELISA Kit|
|ITGA3||ITGA3 Antibody||ITGA3 Protein||ITGA3 cDNA||ITGA3 ELISA Kit|
|ITGA4||ITGA4 Antibody||ITGA4 Protein||ITGA4 cDNA||ITGA4 ELISA Kit|
|ITGA5||ITGA5 Antibody||ITGA5 Protein||ITGA5 cDNA||ITGA5 ELISA Kit|
|ITGA6||ITGA6 Antibody||ITGA6 Protein||ITGA6 cDNA||ITGA6 ELISA Kit|
|ITGA7||ITGA7 Antibody||ITGA7 Protein||ITGA7 cDNA||ITGA7 ELISA Kit|
|ITGA8||ITGA8 Antibody||ITGA8 Protein||ITGA8 cDNA||ITGA8 ELISA Kit|
|ITGA9||ITGA9 Antibody||ITGA9 Protein||ITGA9 cDNA||ITGA9 ELISA Kit|
|ITGAV||ITGAV Antibody||ITGAV Protein||ITGAV cDNA||ITGAV ELISA Kit|
|ITGB1||ITGB1 Antibody||ITGB1 Protein||ITGB1 cDNA||ITGB1 ELISA Kit|
|ITGB3||ITGB3 Antibody||ITGB3 Protein||ITGB3 cDNA||ITGB3 ELISA Kit|
|ITGB4||ITGB4 Antibody||ITGB4 Protein||ITGB4 cDNA||ITGB4 ELISA Kit|
|ITGB5||ITGB5 Antibody||ITGB5 Protein||ITGB5 cDNA||ITGB5 ELISA Kit|
|ITGB6||ITGB6 Antibody||ITGB6 Protein||ITGB6 cDNA||ITGB6 ELISA Kit|
|ITGB7||ITGB7 Antibody||ITGB7 Protein||ITGB7 cDNA||ITGB7 ELISA Kit|