The phosphatidylinositol 3' –kinase (PI3K)-Akt signaling pathway is an intracellular signaling pathway important in regulating the cell cycle and is activated by many types of cellular stimuli or toxic insults.
It regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival in response to extracellular signals. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates.
As shown in following picture, activation of growth factor receptor protein tyrosine kinases including epidermal growth factor receptor (EGFR) by external growth factors results in auto-phosphorylation on tyrosine residues and subsequent events to activate these intracellular pathways.
PI3K is recruited to the membrane by directly binding to phosphotyrosine consensus residues of growth factor receptors or adaptors through one or both SH2 domains in the adaptor subunit. This leads to allosteric activation of the catalytic subunit. Activation results in production of the second messenger phosphatidylinositol-3, 4, 5-trisphosphate (PIP3).
The lipid product of PI3K, PIP3, recruits a subset of signaling proteins with pleckstrin homology (PH) domains to the membrane, including PDK1 and Akt. PTEN, is a PI-3, 4, 5-P3 phosphatase, which negatively regulates the PI3K/Akt pathway.
Once activated, Akt mediates the activation and inhibition of several targets, resulting in cellular survival, growth and proliferation through various mechanisms.
In the mechanism of PI3K-Akt signaling pathway, the key molecules involved in this signaling pathway are receptor tyrosine kinase (RTKs), phosphatidylinositol 3-kinase (PI3K), phosphatidylinositol-4,5-bisphosphate (PIP2), phosphatidylinositol-3,4,5-bisphosphate (PIP3) and AKT/protein kinase B. You can click the link below to view more introduction of the two critical molecules https://www.cusabio.com/c-20715.html.
This article was written by a sweet guy from CUSABIO named PI3K-Akt Signaling Pathway and Cancer, including its history, mechanism and related diseases.
Here is the figure of PI3K-Akt signaling pathway. You can click the image to enlarge it.
|AKT1||AKT1 Antibody||AKT1 Protein||AKT1 cDNA||AKT1 ELISA Kit|
|AKT2||AKT2 Antibody||AKT2 Protein||AKT2 cDNA||AKT2 ELISA Kit|
|AKT3||AKT3 Antibody||AKT3 Protein||AKT3 cDNA||AKT3 ELISA Kit|
|ANGPT1||ANGPT1 Antibody||ANGPT1 Protein||ANGPT1 cDNA||ANGPT1 ELISA Kit|
|ANGPT2||ANGPT2 Antibody||ANGPT2 Protein||ANGPT2 cDNA||ANGPT2 ELISA Kit|
|ANGPT4||ANGPT4 Antibody||ANGPT4 Protein||ANGPT4 cDNA||ANGPT4 ELISA Kit|
|AREG||AREG Antibody||AREG Protein||AREG cDNA||AREG ELISA Kit|
|ATF2||ATF2 Antibody||ATF2 Protein||ATF2 cDNA||ATF2 ELISA Kit|
|ATF4||ATF4 Antibody||ATF4 Protein||ATF4 cDNA||ATF4 ELISA Kit|
|ATF6B||ATF6B Antibody||ATF6B Protein||ATF6B cDNA||ATF6B ELISA Kit|
|BAD||BAD Antibody||BAD Protein||BAD cDNA||BAD ELISA Kit|
|BCL2||BCL2 Antibody||BCL2 Protein||BCL2 cDNA||BCL2 ELISA Kit|
|BCL2L1||BCL2L1 Antibody||BCL2L1 Protein||BCL2L1 cDNA||BCL2L1 ELISA Kit|
|BCL2L11||BCL2L11 Antibody||BCL2L11 Protein||BCL2L11 cDNA||BCL2L11 ELISA Kit|
|BDNF||BDNF Antibody||BDNF Protein||BDNF cDNA||BDNF ELISA Kit|
|BRCA1||BRCA1 Antibody||BRCA1 Protein||BRCA1 cDNA||BRCA1 ELISA Kit|
|CASP9||CASP9 Antibody||CASP9 Protein||CASP9 cDNA||CASP9 ELISA Kit|
|CCND1||CCND1 Antibody||CCND1 Protein||CCND1 cDNA||CCND1 ELISA Kit|
|CCND2||CCND2 Antibody||CCND2 Protein||CCND2 cDNA||CCND2 ELISA Kit|
|CCND3||CCND3 Antibody||CCND3 Protein||CCND3 cDNA||CCND3 ELISA Kit|