C5AR1

C5AR1 (C5a allergenic toxin chemotactic receptor, C5a-R or CD88) is a classical G protein-coupled receptor. C5AR1, also known as the complement fragment C5a receptor. C5AR1 is expressed primarily on granulocytes, monocytes, dendritic cells, and MDSCs (myeloid-derived suppressor cells) in a variety of tumor tissues. C5AR1 plays a key role in the innate immune response. Numerous studies have shown that targeting this process can cause a variety of related diseases, including chronic kidney disease, cardiovascular disease, neurological disorders, and cancer.

As part of the complement system, C5AR1 interacts with C5a, which in turn exerts pro-inflammatory signals. Abnormal complement activation leads to excessive C5AR1-C5a signals, which in turn triggers the body's self-attack and overreaction that is the cause of many auto-inflammatory diseases. In patients with COVID-19, scientists have found that activation of the C5AR1-C5aR recruits and activates lung neutrophils and monocytes, which are involved in ARDS development. The study noted that increased soluble C5a was proportional to COVID-19 severity; also, C5AR1 expression was increased in myeloid-derived cells in peripheral blood and lung, suggesting that the C5AR1-C5aR axis may be involved in ARDS development.

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Popular Product

Recombinant Human C5a anaphylatoxin chemotactic receptor 1(C5AR1)-VLPs (Active) (CSB-MP003996HU)

Validated Data

The binding activity of antigen-antibody validated by functional ELISA

Immobilized human C5AR1 at 10 μg/ml can bind Anti-C5AR1 recombinant antibody (CSB-RA003996A0HU), the EC₅₀ is 1.239-3.760 ng/mL.

The accuracy of structure determined
by TEM

The presence of VLP-like structures was confirmed by TEM