C5AR1, complement component 5a receptor 1, alias CD88. it is a G protein-coupled receptor expressed mainly on granulocytes, monocytes, dendritic cells and myeloid-derived suppressor cells (MDSC) as well as tumor cells.
The mechanism of action of C5AR1 is to activate downstream G protein and β-inhibin signaling pathways by binding to the complement activation fragment C5a, thus playing a key role in the innate immune response. Dysfunction of the C5a-C5aR1 axis is associated with many inflammatory and immune-mediated diseases, including tumor development.
C5AR1 is not only involved in the activation and chemotaxis of immune cells, but is also associated with the immunoregulation of the tumor microenvironment, and its expression level is elevated in a variety of tumors, which can be predictive of biomarkers of disease progression and prognosis, as well as a potential therapeutic target.
Recombinant Human C5a anaphylatoxin chemotactic receptor 1 (C5AR1)-VLPs (Active) (CSB-MP003996HU)
Validated Data
CSB-MP003996HU is detected by Mouse anti-6*His monoclonal antibody.
Activity
Measured by its binding ability in a functional ELISA. Immobilized human C5AR1 at 10 μg/ml can bind Anti-C5AR1 recombinant antibody (CSB-RA003996A0HU), the EC50 is 1.239-3.760 ng/mL.
The presence of VLP-like structures was confirmed by TEM
C5AR1 Recombinant Monoclonal Antibody (CSB-RA003996A0HU)
Validated Data
The Binding Activity of Human C5AR1-VLPs with Anti-C5AR1 recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human C5AR1 (CSB-MP003996HU) at 10 μg/mL can bind Anti-C5AR1 recombinant antibody, the EC50 is 1.239-3.760 ng/mL.
The following C5AR1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
C5AR1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA003996GA01HU | C5AR1 Antibody | Human,Mouse,Rat | ELISA,WB,IF |
CSB-PA001479 | C5AR1 Antibody | Human | WB, IHC, IF, ELISA |
CSB-PA060025 | Phospho-C5AR1 (S338) Antibody | Human | IHC, ELISA |
CSB-PA003996LA01HU | C5AR1 Antibody | Human | ELISA, WB, IHC |
CSB-RA003996A0HU | C5AR1 Recombinant Monoclonal Antibody | Human | ELISA |
C5AR1 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA003996XA01DIL | c5ar1 Antibody | Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
C5AR1 Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-CF003996MOW | Recombinant Macaca mulatta (Rhesus macaque) C5a anaphylatoxin chemotactic receptor (C5AR1) | in vitro E.coli expression system |
CSB-YP003996MOW1 CSB-EP003996MOW1 CSB-BP003996MOW1 CSB-MP003996MOW1 CSB-EP003996MOW1-B |
Recombinant Macaca mulatta (Rhesus macaque) C5a anaphylatoxin chemotactic receptor (C5AR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
C5AR1 Proteins for Pongo pygmaeus (Bornean orangutan)
Code | Product Name | Source |
---|---|---|
CSB-CF003996EXP | Recombinant Pongo pygmaeus C5a anaphylatoxin chemotactic receptor (C5AR1) | in vitro E.coli expression system |
CSB-YP003996EXP1 CSB-EP003996EXP1 CSB-BP003996EXP1 CSB-MP003996EXP1 CSB-EP003996EXP1-B |
Recombinant Pongo pygmaeus C5a anaphylatoxin chemotactic receptor (C5AR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
C5AR1 Proteins for Gorilla gorilla gorilla (Western lowland gorilla)
Code | Product Name | Source |
---|---|---|
CSB-CF003996GGZ | Recombinant Gorilla gorilla gorilla C5a anaphylatoxin chemotactic receptor (C5AR1) | in vitro E.coli expression system |
CSB-YP003996GGZ1 CSB-EP003996GGZ1 CSB-BP003996GGZ1 CSB-MP003996GGZ1 CSB-EP003996GGZ1-B |
Recombinant Gorilla gorilla gorilla C5a anaphylatoxin chemotactic receptor (C5AR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
C5AR1 Proteins for Pan troglodytes (Chimpanzee)
Code | Product Name | Source |
---|---|---|
CSB-CF003996EQV | Recombinant Pan troglodytes C5a anaphylatoxin chemotactic receptor (C5AR1) | in vitro E.coli expression system |
CSB-YP003996EQV1 CSB-EP003996EQV1 CSB-BP003996EQV1 CSB-MP003996EQV1 CSB-EP003996EQV1-B |
Recombinant Pan troglodytes C5a anaphylatoxin chemotactic receptor (C5AR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
C5AR1 Proteins for Cavia porcellus (Guinea pig)
Code | Product Name | Source |
---|---|---|
CSB-CF003996GU | Recombinant Guinea pig C5a anaphylatoxin chemotactic receptor 1 (C5AR1) | in vitro E.coli expression system |
CSB-YP003996GU1 CSB-EP003996GU1 CSB-BP003996GU1 CSB-MP003996GU1 CSB-EP003996GU1-B |
Recombinant Guinea pig C5a anaphylatoxin chemotactic receptor 1 (C5AR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
C5AR1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Source |
---|---|---|
CSB-CF003996DIL | Recombinant Danio rerio C5a anaphylatoxin chemotactic receptor (c5ar1) | in vitro E.coli expression system |
CSB-YP003996DIL1 CSB-EP003996DIL1 CSB-BP003996DIL1 CSB-MP003996DIL1 CSB-EP003996DIL1-B |
Recombinant Danio rerio C5a anaphylatoxin chemotactic receptor (c5ar1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
C5AR1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF003996MO | Recombinant Mouse C5a anaphylatoxin chemotactic receptor (C5ar1) | in vitro E.coli expression system |
CSB-YP003996MO1 CSB-BP003996MO1 CSB-MP003996MO1 |
Recombinant Mouse C5a anaphylatoxin chemotactic receptor (C5ar1), partial | Yeast Baculovirus Mammalian cell |
C5AR1 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Code | Product Name | Source |
---|---|---|
CSB-CF747619OEI | Recombinant Oncorhynchus mykiss C5a anaphylatoxin chemotactic receptor (c5ar1) | in vitro E.coli expression system |
CSB-YP747619OEI1 CSB-EP747619OEI1 CSB-BP747619OEI1 CSB-MP747619OEI1 CSB-EP747619OEI1-B |
Recombinant Oncorhynchus mykiss C5a anaphylatoxin chemotactic receptor (c5ar1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
C5AR1 Proteins for Oryctolagus cuniculus (Rabbit)
Code | Product Name | Source |
---|---|---|
CSB-CF874687RB | Recombinant Rabbit C5a anaphylatoxin chemotactic receptor (C5AR1) | in vitro E.coli expression system |
CSB-YP874687RB1 CSB-EP874687RB1 CSB-BP874687RB1 CSB-MP874687RB1 CSB-EP874687RB1-B |
Recombinant Rabbit C5a anaphylatoxin chemotactic receptor (C5AR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
C5AR1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
Code | Product Name | Source |
---|---|---|
CSB-CF003996DO | Recombinant Dog C5a anaphylatoxin chemotactic receptor 1 (C5AR1) | in vitro E.coli expression system |
CSB-YP003996DO1 CSB-EP003996DO1 CSB-BP003996DO1 CSB-MP003996DO1 CSB-EP003996DO1-B |
Recombinant Dog C5a anaphylatoxin chemotactic receptor 1 (C5AR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
C5AR1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-CF003996RA | Recombinant Rat C5a anaphylatoxin chemotactic receptor (C5ar1) | in vitro E.coli expression system |
CSB-YP003996RA1 CSB-EP003996RA1 CSB-BP003996RA1 CSB-MP003996RA1 CSB-EP003996RA1-B |
Recombinant Rat C5a anaphylatoxin chemotactic receptor (C5ar1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
C5AR1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP003996HU1 CSB-BP003996HU1 CSB-MP003996HU1 |
Recombinant Human C5a anaphylatoxin chemotactic receptor (C5AR1), partial | Yeast Baculovirus Mammalian cell |
CSB-CF003996HUd7 | Recombinant Human C5a anaphylatoxin chemotactic receptor 1 (C5AR1) | in vitro E.coli expression system |
CSB-MP003996HU | Recombinant Human C5a anaphylatoxin chemotactic receptor 1 (C5AR1)-VLPs (Active) | Mammalian cell |
CSB-EP003996HU1 | Recombinant Human C5a anaphylatoxin chemotactic receptor (C5AR1), partial | E.coli |
CSB-EP003996HU1-B | Recombinant Human C5a anaphylatoxin chemotactic receptor (C5AR1), partial,Biotinylated | E.coli |