CD70

CD70 serves as a ligand for CD27 and plays a pivotal role in the immune system, particularly in the activation and proliferation of T cells. Its structure comprises an extracellular domain capable of binding to the CD27 receptor, a transmembrane region, and a cytoplasmic domain. One of the primary functions of CD70 is to regulate T cell activation and proliferation through interaction with the CD27 receptor. CD27 is a molecule present on the surface of T cells, and when CD70 binds to it, it activates multiple signaling pathways, including NF-κB, MAPK, and PI3K-Akt. The activation of these signaling pathways promotes cell proliferation, differentiation, and functional execution, thereby enhancing the immune response. Additionally, CD70 can also influence the function of other immune cells, such as B cells and natural killer cells. Therefore, a thorough understanding of its structure, function, and signaling pathways holds significant implications for immune modulation and the treatment of related diseases.

Popular Product:

Recombinant Human CD70 antigen (CD70), partial (Active)

Validated Data

WB

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced/non-reduced) with 5% enrichment gel and 15% separation gel.

ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD70 at 2 μg/ml can bind Anti-CD70 antibody, the EC₅₀ is 2.414-3.196 ng/mL