FCGR3A (Fc fragment of IgG receptor IIIa), also known as CD16a, is a cell membrane-bound Fc receptor. It belongs to the Fcγ receptor family and is primarily expressed on the surface of immune cells such as natural killer cells (NK cells) and macrophages. Its main function is to mediate antibody-dependent cell-mediated cytotoxicity (ADCC) by binding to the Fc region of immunoglobulin G (IgG). When specific antibodies bind to antigens on the surface of target cells, the ADCC process activates FCGR3A on immune cells. This activation prompts these immune cells to release toxins and cytokines, leading to the destruction or elimination of the target cells. FCGR3A plays a critical role in immune responses and antibody-mediated immune effects. Its role in immunotherapy is increasingly gaining attention.
● FCGR3A Recombinant Monoclonal Antibody CSB-RA008543MA1HU
Validated Data
Immunofluorescence staining of Hela cell with CSB-RA008543MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
The following FCGR3A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
FCGR3A Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA287660 | FCGR3A Antibody |
Human | ELISA,IHC |
CSB-PA183080 | FCGR3A Antibody |
Human | ELISA,IHC |
CSB-PA008543LA01HU | FCGR3A Antibody |
Human | ELISA, IHC, IF |
CSB-PA008543LB01HU | FCGR3A Antibody, HRP conjugated |
Human | ELISA |
CSB-PA008543LC01HU | FCGR3A Antibody, FITC conjugated |
Human | |
CSB-PA008543LD01HU | FCGR3A Antibody, Biotin conjugated |
Human | ELISA |
CSB-RA008543MA1HU | FCGR3A Recombinant Monoclonal Antibody |
Human | ELISA, IF |
FCGR3A Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP303590BO CSB-EP303590BO CSB-BP303590BO CSB-MP303590BO CSB-EP303590BO-B |
Recombinant Bovine Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP388701MOW CSB-EP388701MOW CSB-BP388701MOW CSB-MP388701MOW CSB-EP388701MOW-B |
Recombinant Macaca mulatta Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP636747PI CSB-EP636747PI CSB-BP636747PI CSB-MP636747PI CSB-EP636747PI-B |
Recombinant Pig Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Code | Product Name | Source |
---|---|---|
CSB-YP854680MOV CSB-EP854680MOV CSB-BP854680MOV CSB-MP854680MOV CSB-EP854680MOV-B |
Recombinant Macaca fascicularis Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF008543HU | Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A) |
in vitro E.coli expression system |
CSB-YP008543HU1 CSB-EP008543HU1 CSB-BP008543HU1 CSB-MP008543HU1 CSB-EP008543HU1-B |
Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP005111HU | Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A), partial (Active) |
Mammalian cell |
CSB-EP008543HU2 | Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A), partial |
E.coli |
FCGR3A ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL008543HU | Human Low affinity immunoglobulin gamma Fc region receptor III-A(FCGR3A) ELISA kit |
serum, plasma, tissue homogenates | 11.75 pg/mL |