FCGR3A, the Fc fragment of IgG receptor IIIa, alias CD16a. it is a low-affinity receptor for the Fc region of IgG, a member of the immunoglobulin superfamily, which is mainly expressed on the surface of immune effector cells, such as natural killer (NK) cells, macrophages, mast cells, and neutrophils. fcGR3A induces, by binding to the Fc segment of IgG1 and IgG3, the The cytotoxicity of immune effector cells, i.e., antibody-dependent cell-mediated cytotoxicity (ADCC), kills target cells, and also promotes the secretion of cytokines, such as IFN-γ, TNF, and matrix metalloproteinases, which affects cellular immune function.
The biological significance of FCGR3A is mainly manifested in the multiple immune responses in which it is involved. It not only plays a role in NK cell-mediated ADCC, but also is an important binding site for monoclonal antibody-mediated molecular targeting therapy, which is especially widely used in the treatment of malignant tumors. In addition, genetic polymorphisms of FCGR3A have been associated with therapeutic responses in some cancers, and its expression level may correlate with the prognosis of tumors, contributing to its use as a prognostic biomarker.The expression of FCGR3A also positively correlates with immune checkpoint molecules as well as with tumor-associated macrophage (TAM) gene markers, suggesting that it may play an important role in the tumor immune microenvironment.
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FCGR3A Recombinant Monoclonal Antibody (CSB-RA008543MA1HU)
Validated Data
Immunofluorescence staining of Hela cell with CSB-RA008543MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
The following FCGR3A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
FCGR3A Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA287660 | FCGR3A Antibody | Human | ELISA,IHC |
CSB-PA183080 | FCGR3A Antibody | Human | ELISA,IHC |
CSB-PA008543LA01HU | FCGR3A Antibody | Human | ELISA, IHC, IF |
CSB-PA008543LB01HU | FCGR3A Antibody, HRP conjugated | Human | ELISA |
CSB-PA008543LC01HU | FCGR3A Antibody, FITC conjugated | Human | |
CSB-PA008543LD01HU | FCGR3A Antibody, Biotin conjugated | Human | ELISA |
CSB-RA008543MA1HU | FCGR3A Recombinant Monoclonal Antibody | Human | ELISA, IF |
FCGR3A Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP303590BO CSB-EP303590BO CSB-BP303590BO CSB-MP303590BO CSB-EP303590BO-B |
Recombinant Bovine Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP388701MOW CSB-EP388701MOW CSB-BP388701MOW CSB-MP388701MOW CSB-EP388701MOW-B |
Recombinant Macaca mulatta Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP636747PI CSB-EP636747PI CSB-BP636747PI CSB-MP636747PI CSB-EP636747PI-B |
Recombinant Pig Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Code | Product Name | Source |
---|---|---|
CSB-YP854680MOV CSB-EP854680MOV CSB-BP854680MOV CSB-MP854680MOV CSB-EP854680MOV-B |
Recombinant Macaca fascicularis Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF008543HU | Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A) | in vitro E.coli expression system |
CSB-YP008543HU1 CSB-EP008543HU1 CSB-BP008543HU1 CSB-MP008543HU1 CSB-EP008543HU1-B |
Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP005111HU | Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A), partial (Active) | Mammalian cell |
CSB-EP008543HU2 | Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A), partial | E.coli |
CSB-MP008543HU1(M) | Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A)(F176V), partial (Active) | Mammalian cell |
CSB-MP008543HU1(M)k7 | Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A) (F176V), partial | Mammalian cell |
FCGR3A ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL008543HU | Human Low affinity immunoglobulin gamma Fc region receptor III-A(FCGR3A) ELISA kit | serum, plasma, tissue homogenates | 11.75 pg/mL |