Dll Antibody

1. Characterization of Dll expression in the developing nervous system supports a role of Dll in neural development and function PMID: 26472170
2. Distal-less regulatory element that controls gene expression in leg precursor cells recruits multiple Hox, Extradenticle (Exd) and Homothorax (Hth) complexes to mediate dual outputs: thoracic activation and abdominal repression. PMID: 27058369
3. Joint ectopic expression of Dll and Rn is sufficient to cell-autonomously activate endogenous bab2 and LAE-driven reporter expression in wing and haltere cells PMID: 23825964
4. findings show a spot of dark pigment on fly wings emerged from assembly of a novel gene regulatory module in which a set of pigmentation genes evolved to respond to a common transcriptional regulator determining their spatial distribution; the primitive wing spot pattern subsequently diversified through changes in expression pattern of this regulator PMID: 23520110
5. Hox proteins regulate Dll transcription in part by locally modifying chromatin structure at the Dll locus. PMID: 22523743
6. studied a 17kb genomic region in the Dll locus which lies downstream of the coding sequence and found control elements of primary functional importance for the expression of Dll in the leg and in other tissues PMID: 21320482
7. The medial leg fates are established via a regulatory cascade in which Wg+Dpp activate Distalless and then Distalless directly activates dac, with Wg+Dpp as less critical, permissive inputs. PMID: 21497759
8. disco plays a fundamental role in the Dll-dependent patterning of antenna and leg, perhaps as a regulator of Dll gene expression PMID: 19756755
9. Distal-less...specify antenna fates via regulation of multiple genes. PMID: 11934862
10. Hox protein Ultrabithorax (Ubx) suppresses limb formation in the abdomen by repressing the leg selector gene Distalless PMID: 12408801
11. Dll functions in subdividing the thoracic limb primordium. PMID: 15712199
12. These findings provide a complete and high-resolution fate map of the Drosophila appendage primordia, linking the primary domains to specific cis-regulatory elements in Dll. PMID: 19036798

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KEGG: dme:Dmel_CG3629

UniGene: Dm.7063