pop-1 Antibody

1. these results indicate that SYS-1 and POP-1 levels are influenced by the parent cell's SYS-1/POP-1 levels and this may provide an additional mechanism by which POP-1 regulates distinct targets in different developmental contexts. PMID: 26488501
2. we demonstrate that POP-1 (the C. elegans TCF) also activates target genes through HMG and Helper site interactions. PMID: 24516405
3. SYS-1 and POP-1 nuclear levels are regulated in opposite directions; the C terminus of POP-1 is essential for LIT-1 phosphorylation and is specifically bound by the diverged beta-catenin WRM-1 PMID: 21852394
4. Animals with reduced function of the Wnt-pathway downstream effector POP-1 have as many as 67 seam cells. The 'Wnt/beta-catenin asymmetry' pathway is required for the proper stem cell-like asymmetric division of seam cells. PMID: 20849842
5. Study suggests that pop-1 is not critical for mesoderm specification beyond repression of endoderm specification, and reveals that Wnt-modified pop-1 further reinforces endoderm specification by repressing mesoderm fate in endoderm. PMID: 19818340
6. acetylation enhances nuclear retention of POP-1, the Caenorhabditis elegans LEF/TCF homolog, through increasing nuclear import and blocking nuclear export PMID: 12651889
7. Wnt/MAPK signaling downregulates POP-1 levels in responsive cells, in part by increasing nuclear LIT-1 levels, thereby increasing POP-1 phosphorylation and PAR-5-mediated nuclear export. PMID: 15066285
8. The Wnt effector POP-1 and the PAL-1/Caudal homeoprotein collaborate with SKN-1 to activate C. elegans endoderm development. PMID: 16084508
9. TCF protein, POP-1, converts from repressor to activator as a result of Wnt-induced lowering of nuclear levels. PMID: 16112103
10. POP-1/TCF and SYS-1/beta-catenin directly activate transcription of ceh-22/nkx2.5 isoforms in somatic gonadal precursor distal daughter cells. PMID: 16461282
11. The Wnt effector POP-1, its coactivator SYS-1/beta-catenin, and of upstream components including beta-catenin WRM-1 causes all SGP daughters to adopt the proximal fate. PMID: 16890160
12. Reciprocal asymmetry of SYS-1/beta-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans. PMID: 17296929
13. There are two genetic pathways, one increasing SYS-1 and the other decreasing POP-1 levels, robustly elevate the SYS-1-to-POP-1 ratio in the posterior cell, thereby driving A-P differential cell fates. PMID: 17567664
14. Integration of Wnt-dependent and Wnt-independent cell fate specification pathways within the Caenorhabditis genus can occur in different ways. PMID: 18977344

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KEGG: cel:CELE_W10C8.2

STRING: 6239.W10C8.2

UniGene: Cel.19670