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| Code | CSB-PA634226 |
| Product Type | Polyclonal Antibody |
| Size | US$297 |
| Uniprot No. | Q13418 |
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| Immunogen | Synthesized non-phosphopeptide derived from Human ILK around the phosphorylation site of serine 246 (I-F-S(p)-H-P). |
| Raised in | Rabbit |
| Species Reactivity | Human,Mouse |
| Specificity | The antibody detects endogenous levels of total ILK protein. |
| Tested Applications | ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100 |
| Relevance | Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. Hannigan G.E.,Nature 379:91-96(1996). Janji B.,Oncogene 19:3069-3077(2000). Tadic B.,Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases. |
| Form | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality | Polyclonal |
| Alias | 59 kDa serine/threonine protein kinase; EC 2.7.11.1; ILK-1; ILK1; Integrin-linked protein kinase |
| Immunogen Species | Homo sapiens (Human) |
| Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol |
| Target Names | ILK |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Receptor-proximal protein kinase regulating integrin-mediated signal transduction |
| Subcellular Location | Cell junction, focal adhesion, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cell projection, lamellipodium, Cytoplasm, myofibril, sarcomere |
| Protein Families | Protein kinase superfamily, TKL Ser/Thr protein kinase family |
| Tissue Specificity | Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver. |
| Database Links |
HGNC: 6040 OMIM: 602366 KEGG: hsa:3611 STRING: 9606.ENSP00000299421 UniGene: Hs.706355 |
| Pathway |
PPAR signaling pathway
Focal adhesion |
ILK Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA011685GA01HU | ILK Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA00999D0Rb | ILK Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA00999B0Rb | ILK Antibody, HRP conjugated | Human | ELISA |
| CSB-PA00999C0Rb | ILK Antibody, FITC conjugated | Human | ELISA |
| CSB-PA059405 | Phospho-ILK (Ser246) Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA011219 | Phospho-ILK (S246) Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-PA011220 | ILK Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA087041 | ILK Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA941698 | ILK Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
ILK Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA00999A0Rb | ILK Antibody | Human, Mouse, Rat, Zebrafish | ELISA, WB, IHC, IF |
ILK Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP619764HU CSB-EP619764HU CSB-BP619764HU CSB-MP619764HU |
Recombinant Human Integrin-linked protein kinase(ILK) | Yeast E.coli Baculovirus Mammalian cell |
| CSB-RP009994h | Recombinant Human Integrin-linked protein kinase(ILK),partial | E.coli |
ILK ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E10005h | Human integrin-linked kinase 1,ILK-1 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 9.77 pg/mL |
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