ILK (Ab-246) Antibody

Datasheet
Code CSB-PA634226
Product Type Polyclonal Antibody
Size US$297
Uniprot No. Q13418
Image
  • Western blot analysis of extracts from rat liver cells, using ILK (Ab-246) antibody.
  • Immunohistochemistry analysis of paraffin-embedded human brain tissue using ILK (Ab-246) antibody.
Immunogen Synthesized non-phosphopeptide derived from Human ILK around the phosphorylation site of serine 246 (I-F-S(p)-H-P).
Raised in Rabbit
Species Reactivity Human,Mouse
Specificity The antibody detects endogenous levels of total ILK protein.
Tested Applications ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100
Relevance Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

Hannigan G.E.,Nature 379:91-96(1996).
Janji B.,Oncogene 19:3069-3077(2000).
Tadic B.,Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality Polyclonal
Alias 59 kDa serine/threonine protein kinase; EC 2.7.11.1; ILK-1; ILK1; Integrin-linked protein kinase
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Target Names ILK
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Receptor-proximal protein kinase regulating integrin-mediated signal transduction
Subcellular Location Cell junction, focal adhesion, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cell projection, lamellipodium, Cytoplasm, myofibril, sarcomere
Protein Families Protein kinase superfamily, TKL Ser/Thr protein kinase family
Tissue Specificity Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.
Database Links

HGNC: 6040

OMIM: 602366

KEGG: hsa:3611

STRING: 9606.ENSP00000299421

UniGene: Hs.706355

Pathway PPAR signaling pathway
Focal adhesion

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