Apoptosis is an evolutionarily conserved mechanism for the selective removal of aging, damaged or otherwise unwanted cells. It's sometimes referred to as programmed cell death, and indeed, the process of apoptosis follows a controlled, predictable routine.
Apoptosis plays a fundamental role in many physiological processes such as tissue development, and the immune response. Thus, regulation of apoptosis is important for tissue homeostasis and its deregulation can lead to a variety of pathological conditions including carcinogenesis and chemo-resistance.
Apoptosis is mediated primarily through promoting or inhibiting the activation of caspases. Caspases are effectors of cell suicide and cleave multiple substrates, leading to biochemical and morphological changes including mitochondrial outer membrane permeabilization, cell membrane remodeling and blebbing, cell shrinkage, nuclear condensation, and DNA fragmentation.In mammalian systems, the extrinsic death receptor pathway, the intrinsic mitochondrial pathway and endoplasmic reticulum pathway are the major signaling systems that result in the activation of the executioner/effector caspases and the consequent demise of the cell.
All pathways eventually lead to a common pathway or the execution phase of apoptosis. Understanding the apoptosis mechanisms is important and helpful to us in the understanding of the pathogenesis of conditions as a result of disordered apoptosis. Meanwhile, it may help in the development of drugs that target certain apoptotic genes or pathways.
As the figure of apoptosis pathway shows, there are three common ways of apoptosis mediation: apoptosis mediated by mitochondria, apoptosis mediated by endoplasmic reticulum and apoptosis mediated by death receptor.
For the hot topic of crosstalk between autophagy and apoptosis, an intelligible guy has written a review about this topic.
|FOS||FOS Antibody||FOS Protein||FOS cDNA||FOS ELISA Kit|
|GADD45A||GADD45A Antibody||GADD45A Protein||GADD45A cDNA||GADD45A ELISA Kit|
|GADD45B||GADD45B Antibody||GADD45B Protein||GADD45B cDNA||GADD45B ELISA Kit|
|GADD45G||GADD45G Antibody||GADD45G Protein||GADD45G cDNA||GADD45G ELISA Kit|
|GZMB||GZMB Antibody||GZMB Protein||GZMB cDNA||GZMB ELISA Kit|
|HRAS||HRAS Antibody||HRAS Protein||HRAS cDNA||HRAS ELISA Kit|
|HRK||HRK Antibody||HRK Protein||HRK cDNA||HRK ELISA Kit|
|HTRA2||HTRA2 Antibody||HTRA2 Protein||HTRA2 cDNA||HTRA2 ELISA Kit|
|IKBKB||IKBKB Antibody||IKBKB Protein||IKBKB cDNA||IKBKB ELISA Kit|
|IKBKG||IKBKG Antibody||IKBKG Protein||IKBKG cDNA||IKBKG ELISA Kit|
|IL3||IL3 Antibody||IL3 Protein||IL3 cDNA||IL3 ELISA Kit|
|IL3RA||IL3RA Antibody||IL3RA Protein||IL3RA cDNA||IL3RA ELISA Kit|
|ITPR1||ITPR1 Antibody||ITPR1 Protein||ITPR1 cDNA||ITPR1 ELISA Kit|
|ITPR2||ITPR2 Antibody||ITPR2 Protein||ITPR2 cDNA||ITPR2 ELISA Kit|
|ITPR3||ITPR3 Antibody||ITPR3 Protein||ITPR3 cDNA||ITPR3 ELISA Kit|
|JUN||JUN Antibody||JUN Protein||JUN cDNA||JUN ELISA Kit|
|KRAS||KRAS Antibody||KRAS Protein||KRAS cDNA||KRAS ELISA Kit|
|LMNA||LMNA Antibody||LMNA Protein||LMNA cDNA||LMNA ELISA Kit|
|LMNB1||LMNB1 Antibody||LMNB1 Protein||LMNB1 cDNA||LMNB1 ELISA Kit|
|LMNB2||LMNB2 Antibody||LMNB2 Protein||LMNB2 cDNA||LMNB2 ELISA Kit|