The phosphatidylinositol 3' –kinase (PI3K)-Akt signaling pathway is an intracellular signaling pathway important in regulating the cell cycle and is activated by many types of cellular stimuli or toxic insults.
It regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival in response to extracellular signals. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates.
As shown in following picture, activation of growth factor receptor protein tyrosine kinases including epidermal growth factor receptor (EGFR) by external growth factors results in auto-phosphorylation on tyrosine residues and subsequent events to activate these intracellular pathways.
PI3K is recruited to the membrane by directly binding to phosphotyrosine consensus residues of growth factor receptors or adaptors through one or both SH2 domains in the adaptor subunit. This leads to allosteric activation of the catalytic subunit. Activation results in production of the second messenger phosphatidylinositol-3, 4, 5-trisphosphate (PIP3).
The lipid product of PI3K, PIP3, recruits a subset of signaling proteins with pleckstrin homology (PH) domains to the membrane, including PDK1 and Akt. PTEN, is a PI-3, 4, 5-P3 phosphatase, which negatively regulates the PI3K/Akt pathway.
Once activated, Akt mediates the activation and inhibition of several targets, resulting in cellular survival, growth and proliferation through various mechanisms.
In the mechanism of PI3K-Akt signaling pathway, the key molecules involved in this signaling pathway are receptor tyrosine kinase (RTKs), phosphatidylinositol 3-kinase (PI3K), phosphatidylinositol-4,5-bisphosphate (PIP2), phosphatidylinositol-3,4,5-bisphosphate (PIP3) and AKT/protein kinase B. You can click the link below to view more introduction of the two critical molecules https://www.cusabio.com/c-20715.html.
This article was written by a sweet guy from CUSABIO named PI3K-Akt Signaling Pathway and Cancer, including its history, mechanism and related diseases.
Here is the figure of PI3K-Akt signaling pathway. You can click the image to enlarge it.
|ITGB8||ITGB8 Antibody||ITGB8 Protein||ITGB8 cDNA||ITGB8 ELISA Kit|
|JAK1||JAK1 Antibody||JAK1 Protein||JAK1 cDNA||JAK1 ELISA Kit|
|JAK2||JAK2 Antibody||JAK2 Protein||JAK2 cDNA||JAK2 ELISA Kit|
|JAK3||JAK3 Antibody||JAK3 Protein||JAK3 cDNA||JAK3 ELISA Kit|
|KDR||KDR Antibody||KDR Protein||KDR cDNA||KDR ELISA Kit|
|KIT||KIT Antibody||KIT Protein||KIT cDNA||KIT ELISA Kit|
|KITLG||KITLG Antibody||KITLG Protein||KITLG cDNA||KITLG ELISA Kit|
|KRAS||KRAS Antibody||KRAS Protein||KRAS cDNA||KRAS ELISA Kit|
|LAMA1||LAMA1 Antibody||LAMA1 Protein||LAMA1 cDNA||LAMA1 ELISA Kit|
|LAMA2||LAMA2 Antibody||LAMA2 Protein||LAMA2 cDNA||LAMA2 ELISA Kit|
|LAMA3||LAMA3 Antibody||LAMA3 Protein||LAMA3 cDNA||LAMA3 ELISA Kit|
|LAMA4||LAMA4 Antibody||LAMA4 Protein||LAMA4 cDNA||LAMA4 ELISA Kit|
|LAMA5||LAMA5 Antibody||LAMA5 Protein||LAMA5 cDNA||LAMA5 ELISA Kit|
|LAMB1||LAMB1 Antibody||LAMB1 Protein||LAMB1 cDNA||LAMB1 ELISA Kit|
|LAMB2||LAMB2 Antibody||LAMB2 Protein||LAMB2 cDNA||LAMB2 ELISA Kit|
|LAMB3||LAMB3 Antibody||LAMB3 Protein||LAMB3 cDNA||LAMB3 ELISA Kit|
|LAMB4||LAMB4 Antibody||LAMB4 Protein||LAMB4 cDNA||LAMB4 ELISA Kit|
|LAMC1||LAMC1 Antibody||LAMC1 Protein||LAMC1 cDNA||LAMC1 ELISA Kit|
|LAMC2||LAMC2 Antibody||LAMC2 Protein||LAMC2 cDNA||LAMC2 ELISA Kit|
|LAMC3||LAMC3 Antibody||LAMC3 Protein||LAMC3 cDNA||LAMC3 ELISA Kit|
Join the 25,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.
Sign up now!
We don't deal in spam.