GIPR, gastric inhibitory polypeptide receptor, alias PGQTL2. GIPR is encoded by the human GIPR gene, which is located on chromosome 19 in the q13.32 region. GIPR is a G-protein-coupled receptor, whose endogenous ligand is glucose-dependent insulinotropic polypeptide (GIP), and which plays an important role in adipogenesis, pancreatic β-cell proliferation, and insulin release that are associated with type 2 diabetes, obesity and neurodegenerative diseases.
Binding of GIPR to GIP activates the adenylate cyclase-cyclic adenosine monophosphate-protein kinase A pathway and promotes insulin secretion.GIPR plays a key role in the regulation of postprandial glucose concentration and promotes insulin secretion under hyperglycemic conditions, and stimulates islet α-cells to release glucagon under hypoglycemic conditions, thereby maintaining glucose homeostasis.
Abnormal expression or dysfunction of GIPR may be related to the pathogenesis of diabetes and is a potential target for diabetes treatment.
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis GIPR at 2μg/mL can bind Anti-GIPR recombinant antibody (CSB-RA009438MA1HU),the EC50 is 12.66-13.86 ng/mL.
Recombinant Rat Gastric inhibitory polypeptide receptor (Gipr), partial (Active) (CSB-MP009438RA1)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Rat Gipr at 2μg/mL can bind Anti-Mouse Gipr recombinant antibody (CSB-RA009438MA1MO), the EC50 is 6.946-8.740 ng/mL.
Recombinant Mouse Gastric inhibitory polypeptide receptor (Gipr), partial (Active) (CSB-MP009438MO1)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Gipr at 2μg/mL can bind Anti-Mouse Gipr recombinant antibody (CSB-RA009438MA1MO), the EC50 is 8.622-11.36 ng/mL.
Recombinant Human Gastric inhibitory polypeptide receptor(GIPR),partial (Active) (CSB-MP009438HU1d7)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human GIPR at 2μg/mL can bind Anti-GIPR recombinant antibody (CSB-RA009438MA1HU),the EC50 is 16.18-18.70 ng/mL.
The purity of GIPR was greater than 95% as determined by SEC-HPLC
GIPR Recombinant Monoclonal Antibody (CSB-RA009438MA1HU)
Validated Data
The Binding Activity of Macaca fascicularis GIPR with Anti-GIPR recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis GIPR (CSB-YP4825MOV) at 2 μg/mL can bind Anti-GIPR recombinant antibody. The EC50 is 12.66-13.86 ng/mL.
The Binding Activity of Human GIPR with Anti-GIPR recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GIPR (CSB-MP009438HU1d7) at 2 μg/mL can bind Anti-GIPR recombinant antibody. The EC50 is 16.18-18.70 ng/mL.
The following GIPR reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
GIPR Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA002687 | GIPR Antibody | Human | WB, IHC, IF, ELISA |
CSB-PA057280 | GIPR Antibody | Human,Mouse | ELISA,WB |
CSB-PA214765 | GIPR Antibody | Human,Mouse | ELISA,WB |
CSB-PA009438ESR1HU | GIPR Antibody | Human | ELISA, WB, IHC |
CSB-PA009438ESR2HU | GIPR Antibody | Human | ELISA, IHC, IF |
CSB-RA009438MA2HU | GIPR Recombinant Monoclonal Antibody | Human | ELISA, WB |
CSB-RA009438MA1HU | GIPR Recombinant Monoclonal Antibody | Human, Macaca fascicularis | ELISA |
GIPR Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA009438ZA01MO | Gipr Antibody | Mus musculus | ELISA, WB (ensure identification of antigen) |
CSB-RA009438MA1MO | Gipr Recombinant Monoclonal Antibody | Mouse, Rat | ELISA |
GIPR Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF009438MO | Recombinant Mouse Gastric inhibitory polypeptide receptor (Gipr) | in vitro E.coli expression system |
GIPR Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-CF009438RA | Recombinant Rat Gastric inhibitory polypeptide receptor (Gipr) | in vitro E.coli expression system |
CSB-EP009438RA1 CSB-MP009438RA1 CSB-EP009438RA1-B |
Recombinant Rat Gastric inhibitory polypeptide receptor (Gipr), partial | E.coli Mammalian cell In Vivo Biotinylation in E.coli |
CSB-MP009438RA1 | Recombinant Rat Gastric inhibitory polypeptide receptor (Gipr), partial (Active) | Mammalian cell |
GIPR Proteins for Mesocricetus auratus (Golden hamster)
Code | Product Name | Source |
---|---|---|
CSB-CF009438MRG | Recombinant Mesocricetus auratus Gastric inhibitory polypeptide receptor (GIPR) | in vitro E.coli expression system |
CSB-YP009438MRG1 CSB-EP009438MRG1 CSB-BP009438MRG1 CSB-MP009438MRG1 CSB-EP009438MRG1-B |
Recombinant Mesocricetus auratus Gastric inhibitory polypeptide receptor (GIPR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GIPR Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF009438HU | Recombinant Human Gastric inhibitory polypeptide receptor (GIPR) | in vitro E.coli expression system |
CSB-YP009438HU1 |
Recombinant Human Gastric inhibitory polypeptide receptor (GIPR), partial | Yeast |
CSB-EP009438HU1 | Recombinant Human Gastric inhibitory polypeptide receptor (GIPR), partial | E.coli |
CSB-MP009438HU1 | Recombinant Human Gastric inhibitory polypeptide receptor (GIPR), partial | Mammalian cell |
CSB-BP009438HU1 | Recombinant Human Gastric inhibitory polypeptide receptor (GIPR), partial | Baculovirus |
CSB-EP009438HU1-B | Recombinant Human Gastric inhibitory polypeptide receptor (GIPR), partial,Biotinylated | E.coli |
CSB-MP009438HU1d7 | Recombinant Human Gastric inhibitory polypeptide receptor(GIPR),partial (Active) | Mammalian cell |
CSB-MP009438HU | Recombinant Human Gastric inhibitory polypeptide receptor (GIPR)-VLPs | Mammalian cell |
GIPR Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-BP009438MO1 CSB-MP009438MO1 CSB-EP009438MO1-B |
Recombinant Mouse Gastric inhibitory polypeptide receptor (Gipr), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP009438MO1 | Recombinant Mouse Gastric inhibitory polypeptide receptor (Gipr), partial | E.coli |
CSB-MP009438MO1 | Recombinant Mouse Gastric inhibitory polypeptide receptor (Gipr), partial (Active) | Mammalian cell |