SELE

SELE, or E-selectin, is a cell-surface glycoprotein encoded by the SELE gene that is mainly expressed on activated endothelial cells.The mechanism of action of SELE involves its regulatory role in the inflammatory response, particularly during the adhesion of leukocytes to endothelial cells. When endothelial cells are stimulated by inflammatory mediators such as tumour necrosis factor alpha (TNF-α) or IL-1, SELE expression is up-regulated, which promotes rolling leukocytes to adhere to the endothelial cell surface and migrate further to the site of inflammation.The signalling pathway of SELE involves interactions with ligands on the surface of leukocytes, such as sialyl-Lewis X (sLe^X), which trigger intracellular signalling that enhances intercellular adhesion. Biologically, SELE is essential for the regulation of immune cell migration and participation in inflammatory responses and immunosurveillance.Abnormal expression of SELE has been associated with a variety of pathological processes including atherosclerosis, inflammatory bowel disease and autoimmune diseases.