SELE, or E-selectin, is a cell-surface glycoprotein encoded by the SELE gene that is mainly expressed on activated endothelial cells.The mechanism of action of SELE involves its regulatory role in the inflammatory response, particularly during the adhesion of leukocytes to endothelial cells. When endothelial cells are stimulated by inflammatory mediators such as tumour necrosis factor alpha (TNF-α) or IL-1, SELE expression is up-regulated, which promotes rolling leukocytes to adhere to the endothelial cell surface and migrate further to the site of inflammation.The signalling pathway of SELE involves interactions with ligands on the surface of leukocytes, such as sialyl-Lewis X (sLe^X), which trigger intracellular signalling that enhances intercellular adhesion. Biologically, SELE is essential for the regulation of immune cell migration and participation in inflammatory responses and immunosurveillance.Abnormal expression of SELE has been associated with a variety of pathological processes including atherosclerosis, inflammatory bowel disease and autoimmune diseases.
Recombinant Pig E-selectin (SELE), partial (CSB-EP020975PIe1)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Validated Data
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA056380(SELE Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA056380(SELE Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
The following SELE reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SELE Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA020975GA01HU | SELE Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA056380 | SELE Antibody | Human | ELISA,IHC |
CSB-PA775739 | SELE Antibody | Human | ELISA,IHC |
CSB-PA715369 | SELE Antibody | Human | WB,ELISA |
SELE Antibodies for Pig
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA020975EA01PI | SELE Antibody | Pig | ELISA |
CSB-PA020975EB01PI | SELE Antibody, HRP conjugated | Pig | ELISA |
CSB-PA020975EC01PI | SELE Antibody, FITC conjugated | Pig | |
CSB-PA020975ED01PI | SELE Antibody, Biotin conjugated | Pig | ELISA |
SELE Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-EP020975PI | Recombinant Pig E-selectin (SELE), partial | E.coli |
CSB-YP020975PI | Recombinant Pig E-selectin (SELE), partial | Yeast |
CSB-BP020975PI CSB-MP020975PI CSB-EP020975PI-B |
Recombinant Pig E-selectin (SELE) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SELE Proteins for Oryctolagus cuniculus (Rabbit)
Code | Product Name | Source |
---|---|---|
CSB-YP020975RB | Recombinant Rabbit E-selectin (SELE), partial | Yeast |
CSB-EP020975RB CSB-BP020975RB CSB-MP020975RB CSB-EP020975RB-B |
Recombinant Rabbit E-selectin (SELE) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SELE Proteins for Equus caballus (Horse)
Code | Product Name | Source |
---|---|---|
CSB-YP850178HO CSB-EP850178HO CSB-BP850178HO CSB-MP850178HO CSB-EP850178HO-B |
Recombinant Horse E-selectin (SELE), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SELE Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-CF020975BO | Recombinant Bovine E-selectin (SELE) | in vitro E.coli expression system |
CSB-YP020975BO1 CSB-EP020975BO1 CSB-BP020975BO1 CSB-MP020975BO1 CSB-EP020975BO1-B |
Recombinant Bovine E-selectin (SELE), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SELE Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF020975HU | Recombinant Human E-selectin (SELE) | in vitro E.coli expression system |
CSB-YP020975HU1 CSB-EP020975HU1 CSB-BP020975HU1 CSB-MP020975HU1 CSB-EP020975HU1-B |
Recombinant Human E-selectin (SELE), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SELE Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-CF020975DO | Recombinant Dog E-selectin (SELE) | in vitro E.coli expression system |
CSB-YP020975DO1 CSB-EP020975DO1 CSB-BP020975DO1 CSB-MP020975DO1 CSB-EP020975DO1-B |
Recombinant Dog E-selectin (SELE), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SELE ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04540h | Human E-Selectin ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
SELE ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04541m | Mouse E-Selectin ELISA kit | serum, plasma, tissue homogenates | 19.5 pg/mL |
SELE ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E07996r | Rat soluble E-selectin,sE-selectin ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 19.5 pg/mL |