GLP1R

GLP-1R (Glucagon-Like Peptide-1 Receptor) is a receptor protein belonging to the G protein-coupled receptor family. It is a receptor that interacts with glucagon-like peptide-1 (GLP-1) and plays a critical physiological role in insulin secretion and blood glucose regulation. GLP-1R is located on pancreatic beta cells, and when GLP-1 binds to GLP-1R, it can stimulate the secretion of insulin. In addition to promoting insulin secretion, GLP-1R also inhibits the secretion of glucagon. GLP-1 receptor agonists are a class of drugs commonly used to treat type 2 diabetes. They mimic the action of GLP-1, stimulating insulin secretion and inhibiting glucagon, thereby lowering blood sugar levels. Research on GLP-1R is of significant importance in understanding diseases related to insulin secretion and blood glucose regulation.

Popular Product

Recombinant Human Glucagon-like peptide 1 receptor(GLP1R),partial (Active) CSB-MP009514HUb1

Validated Data

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC₅₀ is 54.54-94.23 ng/mL.