GLP1R

GLP-1R, or Glucagon-Like Peptide-1 Receptor, is a G protein-coupled receptor (GPCR) that binds to the hormone glucagon-like peptide-1 (GLP-1). When GLP-1 binds to GLP-1R, it triggers a series of signal transduction pathways, including activating adenylate cyclase, protein kinase A, and phosphoinositide 3-kinase, ultimately leading to increased insulin secretion and regulation of blood glucose levels. This characteristic makes GLP-1R an important target for diabetes treatment. In diabetes therapy, GLP-1 mimetic drugs are designed to replicate the action of GLP-1 by activating GLP-1R, promoting insulin secretion, and helping regulate blood sugar levels. Research on GLP-1R aims to better understand its role in insulin secretion, blood glucose regulation, and the mechanisms involved in treating metabolic diseases. These studies might provide new insights and methods for treating conditions such as diabetes, obesity, and metabolic disorders.

Popular Product

Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial

Validated Data

SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.