FSHR

Follicle-stimulating hormone receptor (FSHR) is a member of the glycoprotein subfamily in the G protein-coupled receptor superfamily. FSHR is involved in signal transduction by binding to its ligand, follicle stimulating hormone (FSH).

FSH is a glycoprotein hormone secreted by the pituitary gland, and its main role is to promote and maintain normal gonadal development and reproductive function. FSH can stimulate the development of follicles in the ovaries of women and promote spermatogenesis in the testes of men by combining with FSHR. FSH acts primarily through the FSHR-mediated adenylate cyclase-cyclic adenosine monophosphate (cAMP) pathway. FSH has been shown to activate steady-state receptors by specifically binding to the leucine-rich repeats in the extracellular region of FSHR. Activated FSHR stimulates the coupled guanosine-binding protein (Gs protein) located in the inner membrane of the cell membrane to transmit information. Activated Gs protein activates adenylation and promotes the production of the second messenger cAMP in the cytoplasm, and cAMP reactivates protein kinase A to promote protein phosphorylation and achieve physiological effects.

The expression of FSHR is thought to be gonad specific. For a long time, it was thought that the expression of FSHR was limited to the granulosa cells of the ovary and Sertoli cells of the testis, but it was later found that FSHR was expressed in the placenta, uterus, prostate, bone tissue and ovarian epithelial cells as well as in ovarian cancer. In addition, recent studies have found that FSHR is selectively expressed on the surface of many tumor blood vessels, and found that the expression of FSHR is closely related to tumor metastasis in primary renal cell carcinoma. The expression levels of FSHR were also different at different stages of female follicular development.

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Popular Product

Recombinant Human Follicle-stimulating hormone receptor(FSHR),partial（CSB-MP009021HUd9）

Validated Data

High Specifity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.