Notch is a large class of transmembrane receptors. The Notch signaling pathway is a highly conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. Notch signaling is an important pathway for communication between adjacent cells to regulate cell development.
Notch signaling pathway mainly consists of three parts: Notch receptor, Notch ligand (DSL protein) and intracellular effector molecule (CSL-DNA binding protein).
Mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. Their primary function is to bind to the ligand and initiate the Notch signal. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands.
Notch ligand, also known as DSL protein, is a transmembrane protein with a conserved molecular structure. Five Notch ligands are currently known, namely Delta like (DLL1, DLL3, DLL4), Jagged1 and Jagged 2.
Intracellular effector molecules: CBF-1 (C-promoter binding factor-1), which is also called RBP-Jκ (recombination signal binding protein-jκ) in mammals. It's a transcription suppressor. In the Notch signaling pathway, CBF-1 recognizes Notch induction and binds to specific DNA sequences (GTGGGAA) on gene promoters.
The Notch signaling pathway is divided into canonical and non-canonical pathways depending on whether RBP-Jκ is involved in pathway conduction.
The canonical Notch signaling pathway process is as follows:
The unactivated Notch receptor releases a soluble intracellular domain (NICD) after three hydrolysiss. Subsequently, the NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.
Notch signal changes are closely related to the occurrence and development of tumors, genetic diseases, autoimmune diseases and other diseases. The study of this pathway can provide a target for the treatment of diseases.
|HDAC2||HDAC2 Antibody||HDAC2 Protein||HDAC2 cDNA||HDAC2 ELISA Kit|
|HES1||HES1 Antibody||HES1 Protein||HES1 cDNA||HES1 ELISA Kit|
|HES5||HES5 Antibody||HES5 Protein||HES5 cDNA||HES5 ELISA Kit|
|JAG1||JAG1 Antibody||JAG1 Protein||JAG1 cDNA||JAG1 ELISA Kit|
|JAG2||JAG2 Antibody||JAG2 Protein||JAG2 cDNA||JAG2 ELISA Kit|
|KAT2A||KAT2A Antibody||KAT2A Protein||KAT2A cDNA||KAT2A ELISA Kit|
|KAT2B||KAT2B Antibody||KAT2B Protein||KAT2B cDNA||KAT2B ELISA Kit|
|LFNG||LFNG Antibody||LFNG Protein||LFNG cDNA||LFNG ELISA Kit|
|MAML1||MAML1 Antibody||MAML1 Protein||MAML1 cDNA||MAML1 ELISA Kit|
|MAML2||MAML2 Antibody||MAML2 Protein||MAML2 cDNA||MAML2 ELISA Kit|
|MAML3||MAML3 Antibody||MAML3 Protein||MAML3 cDNA||MAML3 ELISA Kit|
|MFNG||MFNG Antibody||MFNG Protein||MFNG cDNA||MFNG ELISA Kit|
|NCOR2||NCOR2 Antibody||NCOR2 Protein||NCOR2 cDNA||NCOR2 ELISA Kit|
|NCSTN||NCSTN Antibody||NCSTN Protein||NCSTN cDNA||NCSTN ELISA Kit|
|NOTCH1||NOTCH1 Antibody||NOTCH1 Protein||NOTCH1 cDNA||NOTCH1 ELISA Kit|
|NOTCH2||NOTCH2 Antibody||NOTCH2 Protein||NOTCH2 cDNA||NOTCH2 ELISA Kit|
|NOTCH3||NOTCH3 Antibody||NOTCH3 Protein||NOTCH3 cDNA||NOTCH3 ELISA Kit|
|NOTCH4||NOTCH4 Antibody||NOTCH4 Protein||NOTCH4 cDNA||NOTCH4 ELISA Kit|
|NUMB||NUMB Antibody||NUMB Protein||NUMB cDNA||NUMB ELISA Kit|
|NUMBL||NUMBL Antibody||NUMBL Protein||NUMBL cDNA||NUMBL ELISA Kit|