The Notch signaling pathway is a highly conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. Mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.
|HDAC2||HDAC2 Antibody||HDAC2 Protein||HDAC2 cDNA||HDAC2 ELISA Kit|
|HES1||HES1 Antibody||HES1 Protein||HES1 cDNA||HES1 ELISA Kit|
|HES5||HES5 Antibody||HES5 Protein||HES5 cDNA||HES5 ELISA Kit|
|JAG1||JAG1 Antibody||JAG1 Protein||JAG1 cDNA||JAG1 ELISA Kit|
|JAG2||JAG2 Antibody||JAG2 Protein||JAG2 cDNA||JAG2 ELISA Kit|
|KAT2A||KAT2A Antibody||KAT2A Protein||KAT2A cDNA||KAT2A ELISA Kit|
|KAT2B||KAT2B Antibody||KAT2B Protein||KAT2B cDNA||KAT2B ELISA Kit|
|LFNG||LFNG Antibody||LFNG Protein||LFNG cDNA||LFNG ELISA Kit|
|MAML1||MAML1 Antibody||MAML1 Protein||MAML1 cDNA||MAML1 ELISA Kit|
|MAML2||MAML2 Antibody||MAML2 Protein||MAML2 cDNA||MAML2 ELISA Kit|
|MAML3||MAML3 Antibody||MAML3 Protein||MAML3 cDNA||MAML3 ELISA Kit|
|MFNG||MFNG Antibody||MFNG Protein||MFNG cDNA||MFNG ELISA Kit|
|NCOR2||NCOR2 Antibody||NCOR2 Protein||NCOR2 cDNA||NCOR2 ELISA Kit|
|NCSTN||NCSTN Antibody||NCSTN Protein||NCSTN cDNA||NCSTN ELISA Kit|
|NOTCH1||NOTCH1 Antibody||NOTCH1 Protein||NOTCH1 cDNA||NOTCH1 ELISA Kit|
|NOTCH2||NOTCH2 Antibody||NOTCH2 Protein||NOTCH2 cDNA||NOTCH2 ELISA Kit|
|NOTCH3||NOTCH3 Antibody||NOTCH3 Protein||NOTCH3 cDNA||NOTCH3 ELISA Kit|
|NOTCH4||NOTCH4 Antibody||NOTCH4 Protein||NOTCH4 cDNA||NOTCH4 ELISA Kit|
|NUMB||NUMB Antibody||NUMB Protein||NUMB cDNA||NUMB ELISA Kit|
|NUMBL||NUMBL Antibody||NUMBL Protein||NUMBL cDNA||NUMBL ELISA Kit|
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