The Notch signaling pathway is a highly conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. Mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.
|PSEN1||PSEN1 Antibody||PSEN1 Protein||PSEN1 cDNA||PSEN1 ELISA Kit|
|PSEN2||PSEN2 Antibody||PSEN2 Protein||PSEN2 cDNA||PSEN2 ELISA Kit|
|PSENEN||PSENEN Antibody||PSENEN Protein||PSENEN cDNA||PSENEN ELISA Kit|
|PTCRA||PTCRA Antibody||PTCRA Protein||PTCRA cDNA||PTCRA ELISA Kit|
|RBPJ||RBPJ Antibody||RBPJ Protein||RBPJ cDNA||RBPJ ELISA Kit|
|RBPJL||RBPJL Antibody||RBPJL Protein||RBPJL cDNA||RBPJL ELISA Kit|
|RFNG||RFNG Antibody||RFNG Protein||RFNG cDNA||RFNG ELISA Kit|
|SNW1||SNW1 Antibody||SNW1 Protein||SNW1 cDNA||SNW1 ELISA Kit|
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