Outer capsid glycoprotein VP7 Antibody

Datasheet
Code CSB-PA420195ZA01RIU
Uniprot No. A8D8S8
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Rotavirus A Outer capsid glycoprotein VP7 (34-309AA)
Raised in Rabbit
Species Reactivity Rotavirus A
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugate
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Outer capsid glycoprotein VP7 (Fragment)
Immunogen Species Rotavirus A (strain RVA/Cow/Canada/C486/1977/G6P6[1]) (RV-A)
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. In integrin-dependent strains, VP7 seems to essentially target the integrin heterodimers ITGAX/ITGB2 and ITGA5/ITGB3 at a postbinding stage, once the initial attachment by VP4 has been achieved (By similarity).
Subcellular Location Virion, Host endoplasmic reticulum lumen
Protein Families Rotavirus VP7 family

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