The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is a chain of interactions between proteins in a cell.
The JAK-STAT signaling pathway transmits information from extracellular chemical signals to the nucleus resulting in DNA transcription and expression of genes involved in immunity, proliferation, differentiation, apoptosis and oncogenesis. This pathway plays a prominent role in mediating signal transduction for many cytokines.
There are three key parts of JAK-STAT signaling pathway: Janus kinases (JAKs), Signal Transducer and Activator of Transcription proteins (STATs), and receptors (which bind the chemical signals). In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors.
Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes.
In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Dysregulation of JAK-STAT signaling is associated with various immune disorders. Accumulating evidence has discovered that STAT3 SNPs is associated with Crohn’s disease, psoriasis and ankylosing spondylitis, STAT4 SNPs is associated with rheumatoid arthritis, Crohn’s disease, systemic lupus erythematosus and Sjogren’s syndrome, and STAT6 SNPs is associated with asthma.
Additionally, given the researches implicating JAK-STAT in autoimmune disease and malignancy, it is not surprising that this pathway has become an attractive target for pharmaceuticals. Ruxolitinib, a JAK1 and JAK2 inhibitor with efficacy for the treatment of polycythemia vera and myelofibrosis, was the first FDA approved JAK inhibitor, or Jakinib.
|SOCS1||SOCS1 Antibody||SOCS1 Protein||SOCS1 ELISA Kit|
|SOCS2||SOCS2 Antibody||SOCS2 Protein||SOCS2 ELISA Kit|
|SOCS3||SOCS3 Antibody||SOCS3 Protein||SOCS3 ELISA Kit|
|SOCS4||SOCS4 Antibody||SOCS4 Protein||SOCS4 ELISA Kit|
|SOCS5||SOCS5 Antibody||SOCS5 Protein||SOCS5 ELISA Kit|
|SOCS6||SOCS6 Antibody||SOCS6 Protein||SOCS6 ELISA Kit|
|SOCS7||SOCS7 Antibody||SOCS7 Protein||SOCS7 ELISA Kit|
|SOS1||SOS1 Antibody||SOS1 Protein||SOS1 ELISA Kit|
|SOS2||SOS2 Antibody||SOS2 Protein||SOS2 ELISA Kit|
|STAM||STAM Antibody||STAM Protein||STAM ELISA Kit|
|STAM2||STAM2 Antibody||STAM2 Protein||STAM2 ELISA Kit|
|STAT1||STAT1 Antibody||STAT1 Protein||STAT1 ELISA Kit|
|STAT2||STAT2 Antibody||STAT2 Protein||STAT2 ELISA Kit|
|STAT3||STAT3 Antibody||STAT3 Protein||STAT3 ELISA Kit|
|STAT4||STAT4 Antibody||STAT4 Protein||STAT4 ELISA Kit|
|STAT5A||STAT5A Antibody||STAT5A Protein||STAT5A ELISA Kit|
|STAT5B||STAT5B Antibody||STAT5B Protein||STAT5B ELISA Kit|
|STAT6||STAT6 Antibody||STAT6 Protein||STAT6 ELISA Kit|
|THPO||THPO Antibody||THPO Protein||THPO ELISA Kit|
|TSLP||TSLP Antibody||TSLP Protein||TSLP ELISA Kit|