The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is a chain of interactions between proteins in a cell.
The JAK-STAT signaling pathway transmits information from extracellular chemical signals to the nucleus resulting in DNA transcription and expression of genes involved in immunity, proliferation, differentiation, apoptosis and oncogenesis. This pathway plays a prominent role in mediating signal transduction for many cytokines.
There are three key parts of JAK-STAT signaling pathway: Janus kinases (JAKs), Signal Transducer and Activator of Transcription proteins (STATs), and receptors (which bind the chemical signals). In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors.
Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes.
In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Dysregulation of JAK-STAT signaling is associated with various immune disorders. Accumulating evidence has discovered that STAT3 SNPs is associated with Crohn’s disease, psoriasis and ankylosing spondylitis, STAT4 SNPs is associated with rheumatoid arthritis, Crohn’s disease, systemic lupus erythematosus and Sjogren’s syndrome, and STAT6 SNPs is associated with asthma.
Additionally, given the researches implicating JAK-STAT in autoimmune disease and malignancy, it is not surprising that this pathway has become an attractive target for pharmaceuticals. Ruxolitinib, a JAK1 and JAK2 inhibitor with efficacy for the treatment of polycythemia vera and myelofibrosis, was the first FDA approved JAK inhibitor, or Jakinib.
|IL21R||IL21R Antibody||IL21R Protein||IL21R cDNA||IL21R ELISA Kit|
|IL22||IL22 Antibody||IL22 Protein||IL22 cDNA||IL22 ELISA Kit|
|IL22RA1||IL22RA1 Antibody||IL22RA1 Protein||IL22RA1 cDNA||IL22RA1 ELISA Kit|
|IL22RA2||IL22RA2 Antibody||IL22RA2 Protein||IL22RA2 cDNA||IL22RA2 ELISA Kit|
|IL23A||IL23A Antibody||IL23A Protein||IL23A cDNA||IL23A ELISA Kit|
|IL23R||IL23R Antibody||IL23R Protein||IL23R cDNA||IL23R ELISA Kit|
|IL24||IL24 Antibody||IL24 Protein||IL24 cDNA||IL24 ELISA Kit|
|IL27RA||IL27RA Antibody||IL27RA Protein||IL27RA cDNA||IL27RA ELISA Kit|
|IL2RA||IL2RA Antibody||IL2RA Protein||IL2RA cDNA||IL2RA ELISA Kit|
|IL2RB||IL2RB Antibody||IL2RB Protein||IL2RB cDNA||IL2RB ELISA Kit|
|IL2RG||IL2RG Antibody||IL2RG Protein||IL2RG cDNA||IL2RG ELISA Kit|
|IL3||IL3 Antibody||IL3 Protein||IL3 cDNA||IL3 ELISA Kit|
|IL3RA||IL3RA Antibody||IL3RA Protein||IL3RA cDNA||IL3RA ELISA Kit|
|IL4||IL4 Antibody||IL4 Protein||IL4 cDNA||IL4 ELISA Kit|
|IL4R||IL4R Antibody||IL4R Protein||IL4R cDNA||IL4R ELISA Kit|
|IL5||IL5 Antibody||IL5 Protein||IL5 cDNA||IL5 ELISA Kit|
|IL5RA||IL5RA Antibody||IL5RA Protein||IL5RA cDNA||IL5RA ELISA Kit|
|IL6||IL6 Antibody||IL6 Protein||IL6 cDNA||IL6 ELISA Kit|
|IL6R||IL6R Antibody||IL6R Protein||IL6R cDNA||IL6R ELISA Kit|
|IL6ST||IL6ST Antibody||IL6ST Protein||IL6ST cDNA||IL6ST ELISA Kit|