The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is a chain of interactions between proteins in a cell.
The JAK-STAT signaling pathway transmits information from extracellular chemical signals to the nucleus resulting in DNA transcription and expression of genes involved in immunity, proliferation, differentiation, apoptosis and oncogenesis. This pathway plays a prominent role in mediating signal transduction for many cytokines.
There are three key parts of JAK-STAT signaling pathway: Janus kinases (JAKs), Signal Transducer and Activator of Transcription proteins (STATs), and receptors (which bind the chemical signals). In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors.
Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes.
In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Dysregulation of JAK-STAT signaling is associated with various immune disorders. Accumulating evidence has discovered that STAT3 SNPs is associated with Crohn’s disease, psoriasis and ankylosing spondylitis, STAT4 SNPs is associated with rheumatoid arthritis, Crohn’s disease, systemic lupus erythematosus and Sjogren’s syndrome, and STAT6 SNPs is associated with asthma.
Additionally, given the researches implicating JAK-STAT in autoimmune disease and malignancy, it is not surprising that this pathway has become an attractive target for pharmaceuticals. Ruxolitinib, a JAK1 and JAK2 inhibitor with efficacy for the treatment of polycythemia vera and myelofibrosis, was the first FDA approved JAK inhibitor, or Jakinib.
|IL7||IL7 Antibody||IL7 Protein||IL7 cDNA||IL7 ELISA Kit|
|IL7R||IL7R Antibody||IL7R Protein||IL7R cDNA||IL7R ELISA Kit|
|IL9||IL9 Antibody||IL9 Protein||IL9 cDNA||IL9 ELISA Kit|
|IL9R||IL9R Antibody||IL9R Protein||IL9R cDNA||IL9R ELISA Kit|
|IRF9||IRF9 Antibody||IRF9 Protein||IRF9 cDNA||IRF9 ELISA Kit|
|JAK1||JAK1 Antibody||JAK1 Protein||JAK1 cDNA||JAK1 ELISA Kit|
|JAK2||JAK2 Antibody||JAK2 Protein||JAK2 cDNA||JAK2 ELISA Kit|
|JAK3||JAK3 Antibody||JAK3 Protein||JAK3 cDNA||JAK3 ELISA Kit|
|LEP||LEP Antibody||LEP Protein||LEP cDNA||LEP ELISA Kit|
|LEPR||LEPR Antibody||LEPR Protein||LEPR cDNA||LEPR ELISA Kit|
|LIF||LIF Antibody||LIF Protein||LIF cDNA||LIF ELISA Kit|
|LIFR||LIFR Antibody||LIFR Protein||LIFR cDNA||LIFR ELISA Kit|
|MCL1||MCL1 Antibody||MCL1 Protein||MCL1 cDNA||MCL1 ELISA Kit|
|MPL||MPL Antibody||MPL Protein||MPL cDNA||MPL ELISA Kit|
|MTOR||MTOR Antibody||MTOR Protein||MTOR cDNA||MTOR ELISA Kit|
|MYC||MYC Antibody||MYC Protein||MYC cDNA||MYC ELISA Kit|
|OSM||OSM Antibody||OSM Protein||OSM cDNA||OSM ELISA Kit|
|OSMR||OSMR Antibody||OSMR Protein||OSMR cDNA||OSMR ELISA Kit|
|PDGFA||PDGFA Antibody||PDGFA Protein||PDGFA cDNA||PDGFA ELISA Kit|
|PDGFB||PDGFB Antibody||PDGFB Protein||PDGFB cDNA||PDGFB ELISA Kit|