hh Antibody

1. Hedgehog signaling from the Posterior Signaling Center maintains U-shaped expression and a prohemocyte population in Drosophila. PMID: 29966604
2. A conserved aspartate residue (D303, or D46) of hedgehog was identified as the general base that activates cholesterol. Mutation of the catalyzing functional group (D303A) reduces activity by >104-fold. This study reports near total rescue of this ostensibly dead general base mutant by a synthetic substrate, 3beta -hydroperoxycholestane in which the sterol -OH group is replaced by the hyper nucleophilic -OOH group. PMID: 28930454
3. Single Aspartate Coordinates Two Catalytic Steps in Hedgehog Autoprocessing PMID: 27529645
4. These findings show that in the wing disc, Hh distributions and signaling are dependent upon basal release and uptake, and on cytoneme-mediated movement. PMID: 28743798
5. Hedgehog (Hh) signaling regulates TORC1 through E2F1 and the cyclin D/Cdk4 complex in the Drosophila eye. PMID: 28829944
6. Role of Hedgehog (Hh) in the testis stem cell niche and the interplay between the Hh signaling mechanisms and those of the JAK-STAT and BMP pathways. Review. PMID: 23807635
7. These results provide evidence that nanoscale organization of Hh regulates the secretion of Hh on ESCRT-derived exovesicles, which in turn act as a vehicle for long-range signaling. PMID: 26490120
8. regulates the pool of PI(4)P associated with Ptc and Smo PMID: 26863604
9. COP9-Hh signaling axis operates in the differentiation niche to promote germline stem cell progeny differentiation PMID: 26672093
10. A local difference in Hedgehog signal transduction increases mechanical cell bond tension and biases cell intercalations along the Drosophila anteroposterior compartment boundary. PMID: 26577205
11. Sonic hedgehog signaling pathway was upregulated in diabetic rat retina and high-glucose cultured Muller cells, and SHH exerted neuroprotective effects on damaged RGCs in a rat diabetes model. PMID: 25813994
12. Hh signalling increases the level of Smo, which then outcompetes Ci for association with PKA and causes a switch in PKA substrate recognition. PMID: 25289679
13. Hh signaling is activated through the JNK pathway and inhibition of Hh signaling in enteroblasts prevents regnerative intestinal stem cell proliferation. PMID: 25753035
14. SMO genes may play an important role in the sonic hedgehog (SHH) pathway and could also be responsible for generating KCOTs and NBCCS. PMID: 25189937
15. study not only reveals an unanticipated and conserved mechanism by which phosphorylation of Ci/Gli positively regulates Hh signaling PMID: 25512501
16. the expression of aPKC is up-regulated by Hh signaling in a Ci-dependent manner PMID: 25349414
17. Hh, previously known only for its local morphogenetic functions, also acts as a lipoprotein-associated endocrine hormone, coordinating the response of multiple tissues to nutrient availability. PMID: 25452274
18. show that Hh secretion in Drosophila wing imaginal discs is dependent on the endosomal sorting complex required for transport (ESCRT) PMID: 25471885
19. Hrs promotes ubiquitination and mediates endosomal trafficking of smoothened in Drosophila hedgehog signaling. PMID: 24244405
20. Dispersion of Hh is also determined by its hydrophobic nature, and the mechanisms that include membrane-tethered transport of Hh are increasingly proposed. PMID: 23747033
21. increasing Hedgehog signalling prevented eye overgrowth induced by the microRNA and Notch pathway PMID: 23667323
22. A pathway by which Hh signaling connects to Rac and Par-1 in cell migration. PMID: 23335293
23. Hh signaling coordinates with JAK-STAT and BMP signaling to regulate the balance of different stem cell populations in the Drosophila testis. PMID: 23419515
24. Shifted (Shf) acts as a highly diffusible 'exchange protein' that weakly binds Hh and reinforces its delivery to other binding partners, or solubulizes Hh to allow exchange between those partners. PMID: 23154411
25. Hedgehog (hh) signals transiently during the specification of the interocellar domain, with homeodomain transcription factor engrailed (en) being required here for hh signaling attenuation. PMID: 23154412
26. In contrast to JAK/STAT signaling, the Hh pathway activity does not impart extended niche function to cyst stem cells (CySCs): Hh only regulates CySC self-renewal. PMID: 23175633
27. Hh signalling is essential for somatic stem cell maintenance in the Drosophila testis niche PMID: 22745310
28. The germline stem cell niche in drosophila ovaries responds to insufficient hedgehog signalling by increasing the range of headgehog spreading. PMID: 22509132
29. Several putative regulators of protein secretion were identified and demonstrated a role for some of these genes in Hh and Wingless (Wg) morphogen secretion in vivo. PMID: 22432040
30. The regulatory activity of Cos2 on Ci proteolysis in wing discs depends on a specific nucleotide-bound conformation that may be regulated by Hh. PMID: 20850429
31. Tissue specificity of Hh targets depends on transcription factors that are Hh-independent, suggesting that ;pre-patterns' of transcription factors partner with Ci to make Hh-dependent gene expression position specific. PMID: 20978080
32. G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila PMID: 20844016
33. Early Hh signaling in the sensory organ precursors confers differential olfactory receptor neurons (ORN) responsiveness to Hh in the brain, such that only axons of low-Ptc ORN classes respond to later signaling by brain-derived Hh. PMID: 20850015
34. phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling PMID: 20435030
35. regulation of Hedgehog transport and stability by glypicans, as well as multiple overlapping feedbacks in the Hedgehog response network, can combine to enhance the robustness of positional specification against variability in Hedgehog levels. PMID: 20363217
36. show that the G1 synchronization that characterizes retinal precursors is the result of the spatially controlled repression of hth by Dpp and Hh, and not of an actively induced cell cycle arres PMID: 20036228
37. Findings identify a role for hedgehog signaling in white/brown adipocyte determination and link in vivo RNAi-based scanning of the Drosophila genome to regulation of adipocyte cell fate in mammals. PMID: 20074523
38. Acts as a somatic stem cell factor in the Drosophila ovary. PMID: 11279500
39. Inductive patterning of the embryonic brain in Drosophila. The loss of Hedgehog expressed in the foregut appears to mediate this effect, as it does in vertebrates. PMID: 11959822
40. paradigm of repression of the Hedgehog response PMID: 12142023
41. Hedgehog body patterning is influenced by dispatched gene product PMID: 12372301
42. hedgehog is negatively regulated by hyperplastic discs in Drosophila PMID: 12421709
43. Trol can mediate signaling through both of the FGF and Hedgehog pathways to control the onset of stem cell proliferation in the developing nervous system. PMID: 12645928
44. identified Hedgehog signal pathway components using RNA interference PMID: 12663920
45. Hh has a role in vein positioning in the Drosophila wing PMID: 12782270
46. Hh promotes the entry of Sxl into the nucleus in the wing disc; in the anterior compartment, Patched (Ptc) is required for this effect, revealing Ptc as a positive effector of Hh PMID: 14597576
47. Signalling properties of this molecule in the embryonic epidermis are examined. PMID: 14602684
48. hh has a role in smo mediation of inhibition of the endosome-associated Hedgehog signaling complex-repressor and activation of Hedgehog signaling complex-activated at the plasma membrane in response to Hh and through interaction with Cos2 PMID: 14645371
49. Hh still occurred in the endocytic vesicles of Hh-receiving cells, suggesting the existence of a second, Patched-independent, mechanism of Hh internalization. PMID: 15102702
50. results support a model in which the ratio of bound to unbound Patched molecules determines the cellular response to Hh PMID: 15300262

Show More

Hide All

KEGG: dme:Dmel_CG4637

STRING: 7227.FBpp0099945

UniGene: Dm.2371