ADR Antibody

Datasheet

Code	CSB-PA335604XA01PIP
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Target Background

Product Details

Full Product Name

Rabbit anti-Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor) ADR Polyclonal antibody

Uniprot No.

P31107

Target Names

ADR

Alternative Names

ADRAdenoregulin antibody; Dermaseptin B2 antibody; Dermaseptin BII antibody

Raised in

Rabbit

Species Reactivity

Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)

Immunogen

Recombinant Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor) ADR protein

Immunogen Species

Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Cationic amphipathic alpha-helical antimicrobial peptide with potent activity against Gram-negative and Gram-positive bacteria, fungi and protozoa. Acts in a synergistic effect in combination with Plasticin-B1 at doses that are not active alone. Acts by disturbing membrane functions. On model mebranes, induces a strong perturbation of anionic lipid bilayers, resides at the hydrocarbon core-water interface, parallel to the plane of the membrane, and interacts preferentially with the polar head groups and glycerol backbone region of the anionic phospholipids, as well as the region of the lipid acyl chain near the bilayer surface. It induces a positive curvature of the bilayer and clustering of anionic lipids, consistent with a carpet mechanism, that may lead to the formation of mixed peptide-phospholipid toroidal, transient pores and membrane permeation/disruption once a threshold peptide accumulation is reached. Also enhances binding of agonists to adenosine A1 receptors (ADORA1), adenosine A2a receptors (ADORA2A), alpha-2 adrenergic receptors (ADRA2A) and 5-hydroxytryptamine 1A receptors (HTR1A). In addition, it enhances guanyl nucleotide exchange which may result in the conversion of receptors to a high affinity state complexed with guanyl nucleotide free G-protein. It affects human behavior eliciting profound malaise, followed by listlessness and then euphoria. It does not show cytotoxic activity on CHO cells. It does not act as a chemoattractant. It does not show hemolytic activity.

Subcellular Location

Secreted. Target cell membrane.

Protein Families

Frog skin active peptide (FSAP) family, Dermaseptin subfamily

Tissue Specificity

Expressed by the skin glands.

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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ADR Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background