TNF (Tumor Necrosis Factor), also known as TNFα, is a cytokine that can directly kill tumor cells without obvious cytotoxicity to normal cells and is a cell signaling protein involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction.
The primary role of TNF signaling pathway is in the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells.
As the figure shows, TNF can bind two receptors, TNFR1 (TNF receptor type 1) and TNFR2 (TNF receptor type 2). TNFR1 is expressed in most tissues, and can be fully activated by both the membrane-bound and soluble trimeric forms of TNF, whereas TNFR2 is found typically in cells of the immune system, and respond to the membrane-bound form of the TNF homotrimer.
As most information regarding TNF signaling is derived from TNFR1, the role of TNFR2 is likely underestimated. Upon binding, TNF triggers the activation of numerous pathways including the NFkB and MAPK pathway.
If you want to know more things about the role of TNFR1 and TNFR2 in TNF signaling pathway, please click here to view the full article entitled "What a paradoxical TNF signaling pathway-Based on Different Receptors".
In this article, besides the role of TNF-TNFR1 and TNF-TNFR2 intersection in TNF signaling pathway, it also compares the difference between TNFR1 and TNFR2 Signaling in Allergy. Maybe it will give your some new ideas about TNF.
Additionally, a sweet guy from CUSABIO summarizes several fundamental information of TNF for someone whom is the first study on TNF, involving the function of TNF, the members of TNF family and related diseases. You can click the following link to view the full text https://www.cusabio.com/c-20601.html.
|CREB1||CREB1 Antibody||CREB1 Protein||CREB1 cDNA||CREB1 ELISA Kit|
|CREB3||CREB3 Antibody||CREB3 Protein||CREB3 cDNA||CREB3 ELISA Kit|
|CREB3L1||CREB3L1 Antibody||CREB3L1 Protein||CREB3L1 cDNA||CREB3L1 ELISA Kit|
|CREB3L2||CREB3L2 Antibody||CREB3L2 Protein||CREB3L2 cDNA||CREB3L2 ELISA Kit|
|CREB3L3||CREB3L3 Antibody||CREB3L3 Protein||CREB3L3 cDNA||CREB3L3 ELISA Kit|
|CREB3L4||CREB3L4 Antibody||CREB3L4 Protein||CREB3L4 cDNA||CREB3L4 ELISA Kit|
|CREB5||CREB5 Antibody||CREB5 Protein||CREB5 cDNA||CREB5 ELISA Kit|
|CSF1||CSF1 Antibody||CSF1 Protein||CSF1 cDNA||CSF1 ELISA Kit|
|CSF2||CSF2 Antibody||CSF2 Protein||CSF2 cDNA||CSF2 ELISA Kit|
|CX3CL1||CX3CL1 Antibody||CX3CL1 Protein||CX3CL1 cDNA||CX3CL1 ELISA Kit|
|CXCL1||CXCL1 Antibody||CXCL1 Protein||CXCL1 cDNA||CXCL1 ELISA Kit|
|CXCL10||CXCL10 Antibody||CXCL10 Protein||CXCL10 cDNA||CXCL10 ELISA Kit|
|CXCL2||CXCL2 Antibody||CXCL2 Protein||CXCL2 cDNA||CXCL2 ELISA Kit|
|CXCL3||CXCL3 Antibody||CXCL3 Protein||CXCL3 cDNA||CXCL3 ELISA Kit|
|CXCL5||CXCL5 Antibody||CXCL5 Protein||CXCL5 cDNA||CXCL5 ELISA Kit|
|DAB2IP||DAB2IP Antibody||DAB2IP Protein||DAB2IP cDNA||DAB2IP ELISA Kit|
|DNM1L||DNM1L Antibody||DNM1L Protein||DNM1L cDNA||DNM1L ELISA Kit|
|EDN1||EDN1 Antibody||EDN1 Protein||EDN1 cDNA||EDN1 ELISA Kit|
|FADD||FADD Antibody||FADD Protein||FADD cDNA||FADD ELISA Kit|
|FAS||FAS Antibody||FAS Protein||FAS cDNA||FAS ELISA Kit|