Spike glycoprotein

Spike glycoprotein comprises two functional subunits responsible for binding to the host cell receptor (S1 subunit) and fusion of the viral and cellular membranes (S2 subunit). For many coronavirus (CoVs), S is cleaved at the boundary between the S1 and S2 subunits, which remain non-covalently bound in the prefusion conformation. The distal S1 subunit comprises the receptor-binding domain(s) and contributes to stabilization of the prefusion state of the membrane-anchored S2 subunit that contains the fusion machinery. S is further cleaved by host proteases at the so-called S2' site located immediately upstream of the fusion peptide in all CoVs. This cleavage has been proposed to activate the protein for membrane fusion via extensive irreversible conformational changes. However, different CoVs use distinct domains within the S1 subunit to recognize a variety of attachment and entry receptors, depending on the viral species. Endemic human coronaviruses OC43 and HKU1 attach via their S domain A to 5-N-acetyl-9-O-acetyl-sialosides found on glycoproteins and glycolipids at the host cell surface to enable entry into susceptible cells. MERS-CoV S uses domain A to recognize non-acetylated sialoside attachment receptors, which likely promote subsequent binding of domain B to the entry receptor, dipeptidyl-peptidase 4. SARS-CoV and several SARS-related coronaviruses (SARSr-CoV) interact directly with angiotensin-converting enzyme 2 (ACE2) via SB to enter target cells.

Spike glycoprotein Antibodies

Spike glycoprotein Antibodies for Human coronavirus OC43

Spike glycoprotein Antibodies for Bovine coronavirus

Spike glycoprotein Antibodies for Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)

Spike glycoprotein Proteins

Spike glycoprotein Proteins for Bovine coronavirus (strain vaccine) (BCoV) (BCV)

Spike glycoprotein Proteins for Human coronavirus OC43 (HCoV-OC43)

Spike glycoprotein Proteins for Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)

Spike glycoprotein Proteins for Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)

Spike glycoprotein Proteins for Human coronavirus NL63 (HCoV-NL63)

Spike glycoprotein Proteins for Human coronavirus 229E (HCoV-229E)

Spike glycoprotein Proteins for Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)

Spike glycoprotein Proteins for Homo sapiens (Human)

Spike glycoprotein ELISA Kit

Spike glycoprotein ELISA Kit for Homo sapiens (Human)


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