Your Good Partner in Biology Research
Your Good Partner in Biology Research
| Code | CSB-PA336163EA01HIY |
| Size |
US$299Purchase it in Cusabio online store (only available for customers from the US) |
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| Full Product Name | Rabbit anti-Human coronavirus OC43 S Polyclonal antibody |
| Uniprot No. | P36334 |
| Target Names | S |
| Alternative Names | S antibody; 3Spike glycoprotein antibody; S glycoprotein antibody; E2 antibody; Peplomer protein) [Cleaved into: Spike protein S1; Spike protein S2; Spike protein S2'] antibody |
| Raised in | Rabbit |
| Species Reactivity | Human coronavirus OC43 |
| Immunogen | Recombinant Human coronavirus OC43 Spike glycoprotein protein (15-344AA) |
| Immunogen Species | Human coronavirus OC43 |
| Conjugate | Non-conjugated The S Antibody (Product code: CSB-PA336163EA01HIY) is Non-conjugated. For S Antibody with conjugates, please check the following table. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification Method | >95%, Protein G purified |
| Concentration | It differs from different batches. Please contact us to confirm it. |
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Form | Liquid |
| Tested Applications | ELISA |
| Protocols | ELISA Protocol |
| Troubleshooting and FAQs | Antibody FAQs |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
Applications : Western Blot Assay
Sample type: Cells
Review: Western blot of the lysates of HCoV-OC43-infected MRC-5 cell streated with kurarinone or vehicle and evaluated at 1,2,3, and 4dpi. The HCoV-OC43 Spike protein was detected and indicated by an arrow head as shown; β-actin was used as a loading control.
By Anonymous
| Function |
S1 attaches the virion to the cell membrane by interacting with sialic acid-containing cell receptors, initiating the infection.; attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.; mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.; Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
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| Subcellular Location | Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. |
| Protein Families | Betacoronaviruses spike protein family |
